Efficient synthesis of tertiary amines from secondary amines

被引：6
|
作者：
Kurosu, Michio [1 ]
Dey, Sevendu Sekhar [1 ]
Crick, Dean C. [1 ]
机构：
[1] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 28期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.tetlet.2006.05.038
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reliable N-alkylations of secondary amines have been developed. By using DIAD and TPP (or PS-TPP) a variety of secondary amines can be converted to the corresponding tertiary amines in good to excellent yields with diverse alkylhalides; no formation of quaternary amine salts are observed. These protocols are amenable to combinatorial chemistry libraries, and are also useful for the syntheses of secondary amines by an acid lysis of the cleavable tertiary amino resins. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4871 / 4875
页数：5
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