The visualization of hERG channels in living cells via a fluorescent probe regulated by the synergy between solvatochromism and molecular rotation based on simple targeting of the group 4-benzylaniline

被引：5

作者：

Qiao, Zhen ^{[1
,2
]}

Zhou, Qiqi ^{[1
,2
]}

Zhang, Hongyi ^{[1
,2
]}

Wei, Ningning ^{[1
,2
]}

Zhang, Yanru ^{[1
,2
]}

Wang, KeWei ^{[2
]}

机构：

[1] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao 266021, Shandong, Peoples R China

[2] Qingdao Univ, Sch Pharm, Dept Med Chem, Qingdao 266021, Shandong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 38期

关键词：

POTASSIUM CHANNEL; DISCOVERY; RECTIFIER;

D O I：

10.1039/c9cc01735f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly sensitive fluorescent probe CBH based on solvatochromism and molecular rotation was designed and developed for imaging of hERG channels by employing a novel targeting group 4-benzylaniline. More importantly, CBH has the potential for the quantitative analysis of the hERG channels expressed in tumor cells.

引用

页码：5515 / 5518

页数：4