Multimodal multiphoton tomograph using a compact femtosecond fiber laser

被引：6
|
作者：
Koenig, Karsten [1 ,2 ]
Batista, Ana [2 ]
Koenig, Aisada [1 ,2 ]
Breunig, Hans Georg [1 ,2 ]
机构：
[1] JenLab GmbH, Johann Hittorf Str 8, D-12489 Berlin, Germany
[2] Saarland Univ, Dept Biophoton & Laser Technol, Saarbrucken, Germany
来源：
MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES XIX | 2019年 / 10882卷
基金：
欧盟地平线“2020”;
关键词：
multiphoton tomography; autofluorescence; SHG; FLIM; dermoscopy; reflectance confocal microscopy; skin; cancer; cosmetics; anti-ageing; in vivo histology; OMI; functional imaging; IN-VIVO; HUMAN SKIN; FACIAL SKIN; RESOLUTION; CRITERIA;
D O I：
10.1117/12.2509551
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Multiphoton tomography based on near infrared femtosecond laser technology has become a versatile high-resolution clinical- and research-imaging tool. Here, we report on a novel moveable multimodal tomograph, the MPTcompact, based on an ultracompact chiller-free fiber-laser system. The tomograph provides in vivo optical biopsies with subcellular resolution as well as optical metabolic imaging capability based on two-photon autofluorescence, second harmonic generation, fluorescence lifetime imaging, reflectance confocal microscopy, and white light CCD imaging. Applications include cancer detection, skin research, cornea research, and in situ evaluation of anti-ageing drugs and pharmaceuticals.
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收藏
页数：6
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