A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles encoding shared tumor antigens for immunotherapy of malignant melanoma

被引：10

作者：

Jabulowsky, Robert A. ^{[1
]}

Loquai, Carmen ^{[2
]}

Mitzel-Rink, Heidrun ^{[2
]}

Utikal, Jochen ^{[3
,4
]}

Gebhardt, Christoffer ^{[3
,4
]}

Hassel, Jessica C. ^{[5
]}

Kaufmann, Roland ^{[6
]}

Pinter, Andreas ^{[6
]}

Derhovanessian, Evelyna ^{[1
]}

Anft, Christine ^{[1
]}

Attig, Sebastian ^{[7
]}

Deubel, Alexandra ^{[1
]}

Diken, Mustafa ^{[7
]}

Gold, Maike ^{[1
]}

Guertler, Claudia ^{[1
]}

Haas, Heinrich ^{[1
]}

Heesen, Ludwig ^{[1
]}

Kemmer-Brueck, Alexandra ^{[1
]}

Kranz, Lena M. ^{[1
]}

Kuehlcke, Klaus ^{[1
]}

Kuhn, Andreas ^{[1
]}

Langguth, Peter ^{[1
]}

Luxemburger, Ulrich ^{[1
]}

Maurus, Daniel ^{[1
]}

Meng, Martin ^{[1
]}

Mueller, Felicitas ^{[1
]}

Rae, Richard ^{[6
,7
]}

Sari, Fatih ^{[1
]}

Schreeb, Katharina ^{[1
]}

Schwarck-Kokarakis, Doreen ^{[1
]}

Stein, Malte ^{[1
]}

Jaeger, Dirk ^{[8
]}

Grabbe, Stephan ^{[2
]}

Kreiter, Sebastian ^{[6
,7
]}

Huber, Christoph ^{[1
]}

Tuereci, Oezlem ^{[9
]}

Sahin, Ugur ^{[1
]}

机构：

[1] BioNTech Corp, Mainz, Germany

[2] Univ Med Ctr Mainz, Dept Dermatol, Mainz, Germany

[3] German Canc Res Ctr, Skin Canc Unit, Heidelberg, Germany

[4] Heidelberg Univ, Univ Med Ctr Mannheim, Dept Dermatol Venereol & Allergol, Mannheim, Germany

[5] Heidelberg Univ Hosp, NCT Heidelberg, Dept Dermatol, Heidelberg, Germany

[6] Goethe Univ Frankfurt, Dept Dermatol Venereol & Allergol, Frankfurt, Germany

[7] Univ Med Ctr Mainz gGmbH, TRON Translat Oncol, Mainz, Germany

[8] Univ Hosp Heidelberg, Natl Ctr Tumor Dis, Med Oncol, Heidelberg, Germany

[9] Cluster Individualized Immune Intervent, Mainz, Germany

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2018-CT156

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CT156

引用

页数：3

共 37 条

[1] A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles encoding shared tumor antigens for immunotherapy of malignant melanoma
Jabulowsky, R. A.
Loquai, C.
Derhovanessian, E.
Mitzel-Rink, H.
Utikal, J.
Hassel, J.
Kaufmann, R.
Pinter, A.
Diken, M.
Gold, M.
Heesen, L.
Schreeb, K. H.
Schwarck-Kokarakis, D.
Kreiter, S.
Gaiser, M. R.
Jaeger, D.
Grabbe, S.
Tuereci, O.
Sahin, U.
ANNALS OF ONCOLOGY, 2018, 29 : 439 - 439
[2] A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles encoding shared tumor antigens for potent melanoma immunotherapy
Heesen, L.
Jabulowsky, R.
Loquai, C.
Utikal, J.
Gebhardt, C.
Hassel, J.
Kaufmann, R.
Pinter, A.
Derhovanessian, E.
Diken, M.
Kranz, L.
Haas, H.
Attig, S.
Kuhn, A.
Langguth, P.
Schwarck-Kokarakis, D.
Jaeger, D.
Grabbe, S.
Tuereci, Oe.
Sahin, U.
ANNALS OF ONCOLOGY, 2017, 28
[3] A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles for potent melanoma immunotherapy
Jabulowsky, Robert A.
Loquai, Carmen
Utikal, Jochen
Hassel, Jessica
Kaufmann, Roland
Derhovanessian, Evelyna
Diken, Mustafa
Kranz, Lena M.
Haas, Heinrich
Attig, Sebastian
Anft, Christine
Buck, Janina
Diekmann, Jan
Fritz, Daniel
Hartmann, Kerstin
Kemmer-Brueck, Alexandra
Kuehlcke, Klaus
Kuhn, Andreas N.
Langguth, Peter
Luxemburger, Ulrich
Meng, Martin
Rae, Richard
Sari, Fatih
Schwarck-Kokarakis, Doreen
Stein, Malte
Grabbe, Stephan
Kreiter, Sebastian
Tuereci, Oezlem
Huber, Christoph
Sahin, Ugur
CANCER RESEARCH, 2017, 77
[4] A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles for potent cancer immunotherapy in patients with malignant melanoma
Jabulowsky, Robert A.
Loquai, Carmen
Diken, Mustafa
Kranz, Lena M.
Haas, Heinrich
Attig, Sebastian
Bidmon, Nicole
Buck, Janina
Derhovanessian, Evelyne
Diekmann, Jan
Fritz, Daniel
Jahndel, Veronika
Kemmer-Brueck, Alexandra
Kuehlcke, Klaus
Kuhn, Andreas N.
Langguth, Peter
Luxemburger, Ulrich
Meng, Martin
Mueller, Felicitas
Rae, Richard
Sari, Fatih
Schwarck-Kokarakis, Doreen
Seck, Christine
Spiess, Kristina
Witt, Meike
Hassel, Jessica C.
Utikal, Jochen
Kaufmann, Roland
Kreiter, Sebastian
Huber, Christoph
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CANCER RESEARCH, 2016, 76
[5] A FIRST-IN-HUMAN (FIH) PHASE I/IIA CLINICAL TRIAL ASSESSING A RIBONUCLEIC ACID LIPOPLEX (RNA-LPX) ENCODING SHARED TUMOR ANTIGENS FOR IMMUNOTHERAPY OF PROSTATE CANCER; PRELIMINARY ANALYSIS OF PRO-MERIT
Linch, Mark
Papai, Zsuzsanna
Takacs, Istvan
Imedio, Esteban Rodrigo
Kuhnle, Marie-Cristine
Derhovanessian, Evelyna
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Sahin, Ugur
Tureci, Ozlem
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A451 - A451
[6] Commencement of first-in-human phase I/II TCR-T clinical trial targeting shared tumor-specific hotspot mutations in solid tumors
Morelli, M. P.
Negrao, M. V.
Jazaeri, A.
Johnson, B.
Kebriaei, P.
Deniger, D.
Collinson-Pautz, M.
Demars, N.
Heymach, J.
Kopetz, S.
ANNALS OF ONCOLOGY, 2022, 33 (07) : S897 - S897
[7] FIRST-IN-HUMAN PHASE I/II CLINICAL TRIAL OF IG-TREGS FOR GVHD PREVENTION
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Christofi, Panagiota
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Miggos, Antonis
Papagregoriou, Charys
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Savvopoulos, Nikolaos
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Vallianou, Ioanna
Sagiadinou, Eleutheria
Tsokanas, Dimitris
Theodorellou, Rodanthy
Papadopoulou, Anastasia
Triantafyllou, Evi
Sakellari, Ioanna
Costeas, Paul
Chatzidimitriou, Anastasia
Yannaki, Evangelia
Spyridonidis, Alexandros
BONE MARROW TRANSPLANTATION, 2024, 59 : 534 - 535
[8] FIRST-IN-HUMAN PHASE I/II CLINICAL TRIAL OF IG-TREGS FOR GVHD PREVENTION
Lysandrou, M.
Kefala, D.
Christofi, P.
Liga, M.
Miggos, A.
Papagregoriou, C.
Vlachonikola, E.
Savvopoulos, N.
Zacharioudaki, V.
Vallianou, I.
Sagiadinou, E.
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Theodorelou, R.
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Triantafyllou, E.
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Costeas, P.
Chatzidimitriou, A.
Yannaki, E.
Spyridonidis, A.
CYTOTHERAPY, 2024, 26 (06) : S12 - S12
[9] IVAC® MUTANOME - A first-in-human phase I clinical trial targeting individual mutant neoantigens for the treatment of melanoma
Miller, Matthias
Loquai, Carmen
Kloke, Bjorn-Philipp
Attig, Sebastian
Bidmon, Nicole
Bolte, Stefanie
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Derhovanessian, Evelyne
Diekmann, Jan
Filbry, Angela
Heesch, Sandra
Hoeller, Christoph
Kuehlcke, Klaus
Langer, David
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Ortseifer, Inga
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Rae, Richard
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Seck, Christine
Spiess, Kristina
Tadmor, Arbel D.
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Kemmer-Brueck, Alexandra
Kuhn, Andreas N.
Luxemburger, Ulrich
Kreiter, Sebastian
Utikal, Jochen
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Tuereci, Oezlem
Sahin, Ugur
CANCER RESEARCH, 2016, 76
[10] IVAC MUTANOME: A first-in-human phase I clinical trial targeting individual mutant neoantigens for the treatment of melanoma
Miller, M.
Sahin, U.
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Kloke, B-P.
Simon, P.
Bukur, V.
Albrecht, C.
Paruzynski, A.
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Schreeb, K.
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Huber, C.
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ANNALS OF ONCOLOGY, 2017, 28

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