A Phase Ib safety and pharmacodynamic study of PXD101 alone and in combination with 5-fluorouracil in patients with advanced solid tumors

被引：1
|
作者：
Northfelt, D.
Ooi, C. E.
Gerwien, R.
Hawthorne, T.
Clarke, A.
Jones, S.
Rodriguez, G.
Buhl-Jensen, P.
Von Hoff, D.
Grem, J.
机构：
[1] Mayo Clin, Scottsdale, AZ USA
[2] CuraGen Corp, Branford, CT USA
[3] Univ Nebraska Med Ctr, Omaha, NE USA
[4] TopoTarget, Copenhagen, Denmark
[5] Translat Genom Res Inst, Phoenix, AZ USA
来源：
EJC SUPPLEMENTS | 2006年 / 4卷 / 12期
关键词：
D O I：
10.1016/S1359-6349(06)70186-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
181
引用
收藏
页码：57 / 57
页数：1
相关论文
共 50 条
  • [1] A phase Ib/II study of PXD101 alone and in combination with 5-fluorouracil in patients with advanced solid tumors
    Northfelt, D. W.
    Marschke, R. F., Jr.
    Bonnem, E.
    Ooi, C. E.
    Gerwien, R.
    Hawthorne, T.
    Clarke, A.
    Buhl-Jensen, P.
    Von Hoff, D.
    Grem, J.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [2] A phase 1 study of belinostat (PXD101) in combination with bortezomib in patients with advanced solid tumors and lymphoma
    O'Bryant, Cindy L.
    Leong, Stephen
    Camidge, D. Ross
    Gore, Lia
    Diab, Sami
    Gustafson, Dan L.
    Call, Justin
    Spratlin, Jennifer
    Zwiebel, James A.
    Eckhardt, S. Gail
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3384S - 3384S
  • [3] A phase 1 study of belinostat (PXD101) in combination with bortezomib in patients with advanced solid tumors or lymphoma
    Nallapareddy, Sujatha
    Leong, Stephen
    Camidge, Ross
    Gore, Lia
    Diab, Sami
    Messersmith, Wells
    Lewis, Karl
    Weekes, Colin
    Gustafson, Daniel
    Jimeno, Antonio
    Zwiebel, James
    -Delgado, Igor Espinoza
    Eckhardt, Gail
    O'Bryant, Cindy
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [4] A phase I study of oral belinostat (PXD101) in patients with advanced solid tumors
    Kelly, W. K.
    Yap, T.
    Lee, J.
    Lassen, U.
    Crowley, E.
    Clarke, A.
    Hawthorne, T.
    Buhl-Jensen, P.
    de Bono, J.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [5] A phase I study of oral belinostat (PXD101) in patients with advanced solid tumors
    Molife, Rhoda
    Lee, James
    Petrylak, Daniel
    Blumenschein, George, Jr.
    Lassen, Ulrik
    Clark, Jayme
    Yap, Timothy
    Rowen, Elin
    Ang, Jooern
    Crowley, Elizabeth
    Clarke, Anne
    Hawthorne, Thomas
    Buhl-Jensen, Peter
    De Bono, Johann
    Kelly, Wm Kevin
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3476S - 3476S
  • [6] A phase I safety, pharmacokinetic and pharmacodynamic study of intravenously administered PXD101 plus carboplatin or paclitaxel or both in patients with advanced solid tumors
    Lassen, U.
    Sorensen, M.
    De Bono, J. S.
    Molife, R.
    Vidal, L.
    Settatree, S.
    Seiden, M. V.
    Li, S. X.
    Jensen, P. B.
    EJC SUPPLEMENTS, 2006, 4 (12): : 111 - 111
  • [7] Final results of a phase I study of oral belinostat (PXD101) in patients with solid tumors
    Kelly, W. K.
    DeBono, J.
    Blumenschein, G.
    Lassen, U.
    Zain, J.
    O'Connor, O.
    Foss, F.
    Tjornelund, J.
    Fagerberg, J.
    Petrylak, D.
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
  • [8] A phase I study of the histone deacetylase (HDAC) inhibitor PXD101 in patients with advanced hematological tumors
    Hansen, M
    Gimsing, P
    Rasmussen, A
    Jensen, PB
    Knudsen, LM
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 225S - 225S
  • [9] A Phase Ib Study of the Simmitecan Single Agent and in Combination With 5-Fluorouracil/Leucovorin or Thalidomide in Patients With Advanced Solid Tumor
    Zhang, Qi
    Deng, Ting
    Yang, Fen
    Guo, Weijian
    Liu, Dan
    Yuan, Jiajia
    Qi, Changsong
    Cao, Yanshuo
    Yu, Qiuqiong
    Cai, Huiming
    Peng, Zhi
    Wang, Xicheng
    Zhou, Jun
    Lu, Ming
    Gong, Jifang
    Li, Jian
    Ba, Yi
    Shen, Lin
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [10] A phase II study of PXD101 in advanced multiple myeloma.
    Sullivan, Daniel
    Singhal, Seema
    Schuster, Michael
    Berenson, James
    Gimsing, Peter
    Wisloff, Finn
    Waage, Anders
    Alsina, Melissa
    Gerwien, Robert
    Clarke, Anne
    Moller, Karen
    Ooi, Chean Eng
    BLOOD, 2006, 108 (11) : 1023A - 1023A
12345