The inhibitory effect of UVB irradiation on the expression of p53 and Ki-67 proteins in arsenic-induced Bowen's disease

被引：11
|
作者：
Chai, CY
Yu, HS
Yen, HT
Tsai, KB
Chen, GS
Yu, CL
机构：
[1] KAOHSIUNG MED COLL,DEPT DERMATOL,KAOHSIUNG 807,TAIWAN
[2] KAOHSIUNG MED COLL,DEPT PATHOL,KAOHSIUNG 807,TAIWAN
[3] KAOHSIUNG MED COLL,GRAD INST MED SCI,KAOHSIUNG 807,TAIWAN
[4] VET GEN HOSP,DEPT MED,TAIPEI,TAIWAN
[5] NATL YANG MING UNIV,SCH MED,TAIPEI 112,TAIWAN
来源：
JOURNAL OF CUTANEOUS PATHOLOGY | 1997年 / 24卷 / 01期
关键词：
D O I：
10.1111/j.1600-0560.1997.tb00779.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The aim of this study is to evaluate the effect of ultraviolet B (WB) on arsenic-induced Bowen's disease. Four patients were irradiated with 750 mJ/cm(2) of UVB and biopsies were performed before treatment and 2 weeks later. Immunohistochemical stains of p53 and Ki-67 were compared by the labelled-streptavidin method before and after the UVB treatment. We found that the number of p53 and Ki-67 positive cells after the UVB treatment were significantly fewer than those of non-UVB-treated specimens. These results suggest that the UVB inhibitory effect in Bowen's disease needs further studies to clarify its value in potentially retarding the progression of the hyperproliferative status in overt skin cancer on a molecular basis. (C) Munksgaard 1997.
引用
收藏
页码：8 / 13
页数：6
相关论文
共 50 条
  • [1] Expression of Ki-67 and p53 in meningiomas
    Pavelin, S.
    Becic, K.
    Forempoher, G.
    Mrklic, I.
    Pogorelic, Z.
    Titlic, M.
    Andelinovic, S.
    NEOPLASMA, 2013, 60 (05) : 480 - 485
  • [2] Heterogeneity of Ki-67 and p53 expression in glioblastomas
    Jakovlevs, A.
    Strumfa, I.
    Vanags, A.
    Gardovskis, J.
    VIRCHOWS ARCHIV, 2014, 465 : S252 - S253
  • [3] KI-67 AND P53 EXPRESSION IN ILEAL POUCHES
    Zurawski, Jakub
    Iwanik, Katarzyna
    Burchardt, Pawel
    Rzymski, Piotr
    Wiktorowicz, Krzysztof
    Ratajczak, Violetta
    Banasiewicz, Tomasz
    Grochowalski, Marcin
    Salwa-Zurawska, Wieslawa
    POLISH JOURNAL OF PATHOLOGY, 2012, 63 (02) : 126 - 130
  • [4] Differential expression of p53 and Ki-67 proteins in classic and iatrogenic Kaposi's sarcoma
    Hodak, E
    Hammel, I
    Feinmesser, M
    Zelinger, A
    Maron, L
    Sulkes, J
    David, M
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1999, 21 (02) : 138 - 145
  • [5] Assessment of p53 and Ki-67 expression in snuff-induced lesions
    Wedenberg, C
    Jonsson, A
    Hirsch, JM
    BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 1996, 34 (05): : 409 - 413
  • [6] Ki-67 and p53 expression in basal cell carcinoma
    Battyáni, Z
    Zombai, E
    Szekeres, G
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (04) : 589 - 589
  • [7] The expression of p53 and Ki-67 in Barrett's esophagus - Their prognostic significance
    Hu, X
    Steinberg, JJ
    FASEB JOURNAL, 1999, 13 (05): : A735 - A735
  • [8] Expression of p53 and Ki-67 proteins in patients with increasing severity and duration of pterygium
    Mahesh, Mood
    Mittal, Sanjeev K.
    Kishore, Sanjeev
    Singh, Anupam
    Gupta, Neeti
    Rana, Rimpi
    INDIAN JOURNAL OF OPHTHALMOLOGY, 2021, 69 (04) : 847 - 850
  • [9] P53, PCNA AND KI-67 EXPRESSION IN EXTRAUTERINE LEIOMYOSARCOMAS
    OREILLY, PE
    RAAB, SS
    NIEMANN, TH
    ROBINSON, RA
    LABORATORY INVESTIGATION, 1995, 72 (01) : A9 - A9
  • [10] Significance of p53 and ki-67 expression in prostate cancer
    Verma, Renuka
    Gupta, Veena
    Singh, Jagjeet
    Verma, Monica
    Gupta, Gopal
    Gupta, Sumiti
    Sen, Rajeev
    Ralli, Megha
    UROLOGY ANNALS, 2015, 7 (04) : 488 - 493
12345