Junjappa-Ila (JI) heteroaromatic annulation:: A new general α-oxoketene dithioacetals mediated inverse method for synthesis of substituted benzothiazoles

被引：2
|
作者：
Hegde, Vinayak S. [1 ]
Kolavi, Gundurao D. [1 ]
Khazi, Imtiyaz Ahmed M. [1 ]
机构：
[1] Karnatak Univ, Dept Chem, Dharwad 580003, Karnataka, India
来源：
SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 20期
关键词：
benzothiazole; JI heteroaromatic annulation; alpha-oxoketene dithioacetal;
D O I：
10.1080/00397910600773775
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-(Methylthio)-5-oxo-2-(2-phenyl-1,3-thiazol-4-yl)-4,5-substituted-pent-2-enenitriles 3a - j were obtained in good yields by condensation of (2-phenyl-1,3-thiazol-4-yl)- acetonitrile ( 1) with various alpha-oxoketene dithioacetals 2a - j in the presence of sodium hydride. The intermediates 3a - j underwent smooth cyclization in the presence of PTSA to afford the corresponding benzothiazoles 4a - j in moderate yields.
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收藏
页码：2983 / 2990
页数：8
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