Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer

被引：16

作者：

Madan, Esha ^{[1
]}

Peixoto, Maria Leonor ^{[1
]}

Dimitrion, Peter ^{[2
,3
,4
]}

Eubank, Timothy D. ^{[5
,6
]}

Yekelchyk, Michail ^{[7
]}

Talukdar, Sarmistha ^{[8
,9
,10
]}

Fisher, Paul B. ^{[8
,9
,10
]}

Mi, Qing-Sheng ^{[2
,3
,4
]}

Moreno, Eduardo ^{[1
]}

Gogna, Rajan ^{[1
]}

机构：

[1] Champalimaud Ctr Unknown, P-1400038 Lisbon, Portugal

[2] Henry Ford Hlth Syst, Ctr Cutaneous Biol & Immunol, Dept Dermatol, Detroit, MI USA

[3] Henry Ford Hlth Syst, Henry Ford Canc Inst, Immunol Res Program, Detroit, MI USA

[4] Wayne State Univ, Med Sch, Dept Biochem Microbiol & Immunol, Detroit, MI USA

[5] West Virginia Univ, Robert C Byrd Hlth Sci Ctr, Vivo Multifunct Magnet Resonance Ctr, Morgantown, WV 26506 USA

[6] West Virginia Univ, Sch Med, Dept Microbiol Immunol & Cell Biol, Morgantown, WV 26506 USA

[7] Max Planck Inst Heart & Lung Res, Dept Cardiac Dev & Remodeling, D-61231 Bad Nauheim, Germany

[8] Virginia Commonwealth Univ, Sch Med, Dept Human & Mol Genet, Richmond, VA USA

[9] Virginia Commonwealth Univ, VCU Massey Canc Ctr, Sch Med, Richmond, VA USA

[10] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Richmond, VA USA

来源：

TRENDS IN CELL BIOLOGY | 2020年 / 30卷 / 12期

关键词：

STEM-CELLS; INFLAMMATION; ROLES; MODEL;

D O I：

10.1016/j.tcb.2020.10.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The comparison of fitness between cells leads to the elimination of less competent cells in the presence of more competent neighbors via cell competition (CC). This phenomenon has been linked with several cancer-related genes and thus may play an important role in cancer. Various processes are involved in the regulation of tumor initiation and growth, including tumor hypoxia, clonal stem cell selection, and immune cell response, all of which have been recently shown to have a potential connection with the mechanisms involved in CC. This review aims to unravel the relation between these processes and competitive cell interactions and how this affects disease progression.

引用

页码：967 / 978

页数：12

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