Ribosome-inactivating lectins of plants

被引：0
|
作者：
Kozlov, Yu. V. [1 ]
Sudarkina, O. Yu.
Kurmanova, A. G.
机构：
[1] VA Engelhardt Mol Biol Inst, Moscow 117984, Russia
[2] Univ Oslo, Ctr Med Res Studies, Moscow, Russia
来源：
MOLECULAR BIOLOGY | 2006年 / 40卷 / 04期
关键词：
ribosome-inactivating protein; RNA N-glycosidase; ricin; lectin; cytotoxicity;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There is a heterogeneous group of plant proteins which are able to enzymatically inactivate ribosomes by depurination of an invariant adenine from the 28 S ribosomal RNA. Some of these proteins are heterodimers having a lectin subunit which is joined by disulfide bond to the enzymatic subunit. Ricin and abrin which are among the most toxic substances known belong to the last group. This review focuses on the structure of the heterodimeric plant ribosome-inactivating proteins, the way of their action on ribosome, biosynthesis, intracellular trafficking, and their possible usage in medicine.
引用
收藏
页码：711 / 723
页数：13
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