Selective removal of silyl protecting groups from hydroxyl functions with ammonium chloride in aqueous acetonitrile

被引：0
|
作者：
Shaabani, A [1 ]
Karimi, AR [1 ]
Alamshahi, AR [1 ]
机构：
[1] Shahid Beheshti Univ, Dept Chem, Tehran, Iran
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2002年 / 41卷 / 09期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Silyl ethers are efficiently hydrolyzed to their corresponding alcohols with NH4Cl in aqueous acetonitrile. Benzylic, secondary and tert-trimethyl silyl ethers are readily cleaved at room temperature, whereas deprotection of primary and some crowded secondary trimethyl silyl ethers takes place at 80degreesC.
引用
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页码：1972 / 1974
页数：3
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