The most compelling reason for practicing judicious antimicrobial use is to facilitate therapeutic success. The definition of therapeutic success has changed in recent years, however; not only does success include eradication of infection, but it must now include avoidance of resistance. If the goal of antimicrobial therapy is to achieve sufficient concentrations at the site of infection such that the infecting organism is killed, therapy should be successful.
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Mayo Clin & Mayo Fdn, Div Infect Dis & Internal Med, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Infect Dis & Internal Med, Rochester, MN 55905 USA
Thompson, RL
Wright, AJ
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Mayo Clin & Mayo Fdn, Div Infect Dis & Internal Med, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Infect Dis & Internal Med, Rochester, MN 55905 USA
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Vet Affairs Ann Arbor Healthcare Syst, Infect Dis Sect 111i, Rm B804,2215 Fuller Rd, Ann Arbor, MI 48105 USAVet Affairs Ann Arbor Healthcare Syst, Infect Dis Sect 111i, Rm B804,2215 Fuller Rd, Ann Arbor, MI 48105 USA