Sensitivity enhancement of DNA sensors by nanogold surface modification

被引：41
|
作者：
Liu, T [1 ]
Tang, J [1 ]
Jiang, L [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Lab Colloid & Interface Sci, Beijing 100080, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 295卷 / 01期
基金：
中国国家自然科学基金;
关键词：
colloidal Au; DNA sensing; quartz crystal microbalanace;
D O I：
10.1016/S0006-291X(02)00628-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel amplified microgravimetric gene sensing system was developed using quartz crystal microbalance modified by gold nanoparticles anchored on its 1,6-hexanedithiol modified gold electrode surface, and ultrasensitive detection of DNA hybridization was accomplished at the level of at least 2 x 10(-16) M. (C) 2002 Elsevier Science (USA). All rights reserved.
引用
收藏
页码：14 / 16
页数：3
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