Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

被引：1

作者：

Milner, R

Anderson, HJ

Rippon, RF

McKay, JS

Franklin, RJM

Marchionni, MA

Reynolds, R

FfrenchConstant, C

机构：

[1] WELLCOME CRC INST DEV BIOL & CANC,CAMBRIDGE CB2 1QR,ENGLAND

[2] UNIV CAMBRIDGE,DEPT MED GENET,CAMBRIDGE CB3 0ES,ENGLAND

[3] UNIV CAMBRIDGE,DEPT CLIN VET MED,CAMBRIDGE CB3 0ES,ENGLAND

[4] UNIV FORVIE SITE,ADDENBROOKES HOSP,MRC,CAMBRIDGE CTR BRAIN REPAIR,CAMBRIDGE CB2 2QQ,ENGLAND

[5] CAMBRIDGE NEUROSCI INC,CAMBRIDGE,MA 02139

[6] CHARING CROSS & WESTMINSTER MED SCH,DEPT ANAT,LONDON W6 8RP,ENGLAND

来源：

GLIA | 1997年 / 19卷 / 01期

基金：

英国惠康基金;

关键词：

myelination; proliferation; platelet derived growth factor (PDGF); basic fibroblast growth factor (bFGF); glial growth factor-2 (GGF-2); neuregulin;

D O I：

10.1002/(SICI)1098-1136(199701)19:1<85::AID-GLIA9>3.0.CO;2-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axone to be myelinated during development. (C) 1997 Wiley-Liss, Inc.

引用

页码：85 / 90

页数：6

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