Tumor-Infiltrating Natural Killer Cells

被引：282

作者：

Cozar, Beatriz ^{[1
]}

Greppi, Marco ^{[1
,2
]}

Carpentier, Sabrina ^{[1
]}

Narni-Mancinelli, Emilie ^{[3
]}

Chiossone, Laura ^{[1
]}

Vivier, Eric ^{[1
,3
,4
]}

机构：

[1] Innate Pharma, Innate Pharma Res Labs, Marseille, France

[2] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy

[3] Aix Marseille Univ, INSERM, CNRS, CIML, Marseille, France

[4] Hop la Timone, AP HM, Serv Immunol, Marseille Immunopole, Marseille, France

来源：

CANCER DISCOVERY | 2021年 / 11卷 / 01期

基金：

欧洲研究理事会; 欧盟地平线“2020”;

关键词：

NK CELLS; LEUKEMIA-CELLS; POOR-PROGNOSIS; EXPRESSION; RECEPTOR; IDENTIFICATION; ACTIVATION; CYTOTOXICITY; EVASION; SUBSETS;

D O I：

10.1158/2159-8290.CD-20-0655

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing target cells and producing cytokines. However, in the immunosuppressive tumor microenvironment, NK cells become dysfunctional through exposure to inhibitory molecules produced by cancer cells, leading to tumor escape. We provide an overview of what is known about NK tumor infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional.

引用

页码：34 / 44

页数：11

共 50 条

[1] Tumor-infiltrating natural killer and T cells in melanoma
Tietze, Julia K.
DERMATOLOGIE, 2022, 73 (12): : 929 - 936
[2] The impact of tumor-infiltrating natural killer cells on ovarian cancer progression
El-Gazzar, Ahmed
Eckelhart, Eva
Perco, Paul
Horvat, Reinhard
Sexl, Veronika
Krainer, Michael
CANCER RESEARCH, 2011, 71
[3] Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells
Bi, Jiacheng
Zheng, Chaoyue
Zheng, Xiaohu
CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (02) : 496 - 497
[4] Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells
Jiacheng Bi
Chaoyue Zheng
Xiaohu Zheng
Cellular & Molecular Immunology, 2021, 18 : 496 - 497
[5] IMMUNOHISTOCHEMICAL STUDY OF NATURAL-KILLER-CELLS IN TUMOR-INFILTRATING LYMPHOCYTES OF PRIMARY INTRACRANIAL GERMINOMAS
VAQUERO, J
COCA, S
MAGALLON, R
PONTON, P
MARTINEZ, R
JOURNAL OF NEUROSURGERY, 1990, 72 (04) : 616 - 618
[6] Prognostic Value of Natural Killer Cells Besides Tumor-Infiltrating Lymphocytes in Breast Cancer Tissues
Bouzidi, Lobna
Triki, Hana
Charfi, Slim
Ben Kridis, Wala
Derbel, Mohamed
Ayadi, Lobna
Sellami-Boudawara, Tahya
Cherif, Boutheina
CLINICAL BREAST CANCER, 2021, 21 (06) : E738 - E747
[7] A Think Tank of TINK/TANKs: Tumor-Infiltrating/Tumor-Associated Natural Killer Cells in Tumor Progression and Angiogenesis
Bruno, Antonino
Ferlazzo, Guido
Albini, Adriana
Noonan, Douglas M.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (08):
[8] Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma
Ombretta Melaiu
Marco Chierici
Valeria Lucarini
Giuseppe Jurman
Libenzio Adrian Conti
Rita De Vito
Renata Boldrini
Loredana Cifaldi
Aurora Castellano
Cesare Furlanello
Vincenzo Barnaba
Franco Locatelli
Doriana Fruci
Nature Communications, 11
[9] Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma
Melaiu, Ombretta
Chierici, Marco
Lucarini, Valeria
Jurman, Giuseppe
Conti, Libenzio Adrian
De Vito, Rita
Boldrini, Renata
Cifaldi, Loredana
Castellano, Aurora
Furlanello, Cesare
Barnaba, Vincenzo
Locatelli, Franco
Fruci, Doriana
NATURE COMMUNICATIONS, 2020, 11 (01)
[10] A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma
Li, Xia-Feng
Dai, Dong
Song, Xiu-Yu
Liu, Jian-Jing
Zhu, Lei
Zhu, Xiang
Ma, Wenchao
Xu, Wengui
ONCOLOGY LETTERS, 2017, 13 (05) : 3291 - 3298

← 1 2 3 4 5 →