Fe-doped beta-tricalcium phosphate; crystal structure and biodegradable behavior with various heating temperature

beta-Tricalcium phosphate (beta-TCP, Ca-3(PO4)(2)) is a kind of biodegradable calcium phosphate ceramics with chemical and mineral compositions similar to those of bone. It is a potential candidate for bone repair surgery. To improve the bioactivity and osteoinductivity of beta-TCP, various ions doped calcium phosphate have been studied. Among them, Iron is a trace element and its deficiency in the human body causes various problems. In this study, we investigated the effect of Fe ions on the structural variation, degradation behavior of beta-TCP. Fe-doped beta-TCP powders were synthesized by the co-precipitation method, and the heat treatment temperature was set at 925 and 1100 degrees C. The structural analysis was carried out by Rietveld refinement using the X-ray diffraction results. Fe ions existed in a different state (Fe2+ or Fe3+) with different heat treatment temperatures, and the substitution sites (Ca-(4) and Ca-(5)) also changed with temperature. The degradation rate was fastest at Fe-doped.-TCP with heated at 1100 degrees C. The cell viability behavior was also enhanced with the substitution of Fe ions. Therefore, the substitution of Fe ion has accelerated the degradation of.-TCP and improved the biocompatibility. It could be more utilized in biomedical devices.