meta-Selective C-H Borylation of Benzamides and Pyridines by an Iridium-Lewis Acid Bifunctional Catalyst

被引：138

作者：

Yang, Lichen ^{[1
]}

Uemura, Nao ^{[1
]}

Nakao, Yoshiaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 19期

关键词：

Iridium;

D O I：

10.1021/jacs.9b03138

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the iridium-catalyzed meta-selective C-H borylation of benzamides by using a newly designed 2,2'-bipyridine (bpy) ligand bearing an alkylaluminum biphenoxide moiety. We also demonstrate the iridium-catalyzed C3-selective C-H borylation of pyridine with a 1,10-phenanthroline (Phen) ligand bearing an alkylborane moiety. It is proposed that the Lewis acid-base interaction between the Lewis acid moiety and the aminocarbonyl group or the sp(2)-hybridized nitrogen atom accelerates the reaction and controls the site-selectivity.

引用

页码：7972 / 7979

页数：8

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