Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis

被引：17
|
作者：
Sedeno-Monge, Virginia [1 ]
Arcega-Revilla, Raul [2 ]
Rojas-Morales, Emmanuel [3 ]
Santos-Lopez, Gerardo [4 ]
Carlos Perez-Garcia, Juan [1 ]
Sosa-Jurado, Francisca [4 ]
Vallejo-Ruiz, Veronica [4 ]
Solis-Morales, Casandra Lucrecia
Aguilar-Rosas, Salvador [5 ]
Reyes-Leyva, Julio [4 ]
机构：
[1] Univ Popular Autonoma Estado Puebla, Fac Med, Puebla, Mexico
[2] Inst Mexicana Seguro Social, Hosp Especialidades, UMAE, Serv Neurol, Puebla, Mexico
[3] Univ Politecn Puebla, Puebla, Mexico
[4] Inst Mexicano Seguro Social, Ctr Invest Biomed Oriente, Lab Biol Mol & Virol, Puebla, Mexico
[5] Univ Popular Autonoma Estado Puebla, Dept Ciencias Biol, Puebla, Mexico
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 273卷 / 1-2期
关键词：
Multiple sclerosis; IFN-beta; SOCS1; SOCS3; INTERFERON-GAMMA; DISEASE-ACTIVITY; EXPRESSION; CELLS; INHIBITOR; PREVENTS; BETA; MICE; ENCEPHALOMYELITIS; OLIGODENDROCYTES;
D O I：
10.1016/j.jneuroim.2014.05.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple sclerosis (MS) is an autoimmune disease characterized by a triad of inflammation, demyelination and gliosis. Because the suPpressors of cytokine signaling (Socs) regulate the immune response, we quantified SOCS1 and SOCS3 transcription in peripheral blood leukocytes of patients with MS. SOCS1 transcription decreased significantly in MS patients compared with neurologically healthy persons (0.08 +/- 0.02 vs. 1.02 +/- 0.23; p = 0.0001); while SOCS3 transcription increased in MS patients compared with controls (2.76 +/- 0.66 vs. 1.03 +/- 0.27; p = 0.0008). Our results showed an imbalance of SOCS1 and SOCS3 transcription in MS patients, and a moderated negative correlation between them (Spearman's r = -0.57; p = 0.0003). (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：117 / 119
页数：3
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