Iron-Catalyzed Arene Alkylation Reactions with Unactivated Secondary Alcohols

被引：45
|
作者：
Jefferies, Latisha R. [1 ]
Cook, Silas P. [1 ]
机构：
[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 07期
基金：
美国国家科学基金会;
关键词：
FRIEDEL-CRAFTS ALKYLATIONS; PROPARGYLIC ALCOHOLS; AROMATIC-COMPOUNDS; BENZYLATION; SUBSTITUTION; DERIVATIVES; BENZENE;
D O I：
10.1021/ol500606d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, iron-based catalytic system allows for the inter- and intramolecular arylation of unactivated secondary alcohols. This transformation expands the substrate scope beyond the previously required activated alcohols and proceeds under mild reaction conditions, tolerating air and moisture. Furthermore, the use of an enantioenriched secondary alcohol provides an enantioenriched product for the intramolecular reaction, thereby offering a convenient approach to nonracemic products.
引用
收藏
页码：2026 / 2029
页数：4
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