Ultrasound triggered image-guided drug delivery to inhibit vascular reconstruction via paclitaxel-loaded microbubbles

被引:42
|
作者
Zhu, Xu [1 ,2 ]
Guo, Jun [1 ,3 ]
He, Cancan [1 ,2 ]
Geng, Huaxiao [1 ,2 ]
Yu, Gengsheng [1 ,2 ]
Li, Jinqing [4 ]
Zheng, Hairong [5 ,6 ]
Ji, Xiaojuan [1 ,2 ]
Yan, Fei [5 ]
机构
[1] Chongqing Med Univ, Childrens Hosp, Dept Cardiol, Chongqing, Peoples R China
[2] Chongqing Key Lab Pediat, Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China
[3] Mianyang Cent Hosp, Dept Pediat, Mianyang, Sichuan, Peoples R China
[4] 324 Hosp PLA, Dept Radiol, Chongqing, Peoples R China
[5] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen, Peoples R China
[6] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Key Lab Nanobiomech, Shenzhen, Peoples R China
来源
SCIENTIFIC REPORTS | 2016年 / 6卷
基金
中国国家自然科学基金;
关键词
IN-STENT RESTENOSIS; ELUTING STENTS; BALLOON ANGIOPLASTY; SIROLIMUS; PREVENTION; ARTERIES; HYPERPLASIA; STENOSIS; EFFICACY; THERAPY;
D O I
10.1038/srep21683
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Paclitaxel (PTX) has been recognized as a promising drug for intervention of vascular reconstructions. However, it is still difficult to achieve local drug delivery in a spatio-temporally controllable manner under real-time image guidance. Here, we introduce an ultrasound (US) triggered image-guided drug delivery approach to inhibit vascular reconstruction via paclitaxel (PTX)-loaded microbubbles (PLM) in a rabbit iliac balloon injury model. PLM was prepared through encapsulating PTX in the shell of lipid microbubbles via film hydration and mechanical vibration technique. Our results showed PLM could effectively deliver PTX when exposed to US irradiation and result in significantly lower viability of vascular smooth muscle cells. Ultrasonographic examinations revealed the US signals from PLM in the iliac artery were greatly increased after intravenous administration of PLM, making it possible to identify the restenosis regions of iliac artery. The in vivo anti-restenosis experiments with PLM and US greatly inhibited neointimal hyperplasia at the injured site, showing an increased lumen area and reduced the ratio of intima area and the media area (I/M ratio). No obvious functional damages to liver and kidney were observed for those animals. Our study provided a promising approach to realize US triggered image-guided PTX delivery for therapeutic applications against iliac restenosis.
引用
收藏
页数:12
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