Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors

被引：1
|
作者：
Chen, H
Udelsman, R
Zeiger, MA
Ball, DW
机构：
[1] JOHNS HOPKINS MED INST,CTR ONCOL,BALTIMORE,MD 21231
[2] JOHNS HOPKINS MED INST,DIV ENDOCRINE & ONCOL SURG,BALTIMORE,MD 21231
[3] JOHNS HOPKINS MED INST,DIV ENDOCRINOL & METAB,BALTIMORE,MD 21231
来源：
ONCOLOGY REPORTS | 1997年 / 4卷 / 04期
关键词：
hASH1; achaete-scute; neuroendocrine; pheochromocytoma; medullary thyroid cancer;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human achaete-scute homolog-1 (hASH1) is critical for establishing the neuroendocrine (NE) phenotype of small cell lung cancer. To define its role in other neoplasms, we analyzed 33 tumors for hASH1 by Northern blotting. Significant levels of hASH1 mRNA were detected in 4 pheochromocytomas, 2 medullary thyroid cancers, and 1 thymic carcinoid. hASH1 transcripts were undetectable in 8 parathyroid lesions, 6 gastrinomas, 4 insulinomas, and 7 thyroid neoplasms, as well as in normal thyroid, adrenal, or pancreas tissue. Therefore, hASH1 mRNA is highly abundant in a subset of human tumors and may play a role in dictating their NE phenotype.
引用
收藏
页码：775 / 778
页数：4
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