Study of expression and functional activity of P-gp membrane glycoprotein in children with acute leukemia

被引：6
|
作者：
Shman, T. V. [1 ]
Savitskii, V. P. [1 ]
Potapnev, M. P. [1 ]
Aleinikova, O. V. [1 ]
机构：
[1] Republican Ctr Children Oncol & Hematol, Minsk, BELARUS
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 06期
关键词：
P-gp; resistance; cytofluorometry; leukemia; prognosis;
D O I：
10.1007/s10517-006-0264-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied expression and functional activity of tumor cell P-gp in children with various leukemia variants and analyzed its prognostic role in acute lymphoblastic leukemia. Functional activity of P-gp increased in acute myeloid leukemia, relapses of acute lymphoblastic leukemia (in comparison with primary disease), and in a group of patients in whom no remission was attained. The survival of patients with acute lymphoblastic leukemia was lower in cases with increased expression and function of P-gp.
引用
收藏
页码：727 / 730
页数：4
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