SYNTHESIS AND ANTI-HIV ACTIVITY OF 4′-MODIFIED CYCLOPENTENYL PYRIMIDINE C-NUCLEOSIDES

被引：5

作者：

Liu, Lian Jin ^{[1
]}

Hong, Joon Hee ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Project Team BK21, Kwangju 501759, South Korea

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2009年 / 28卷 / 04期

关键词：

Cyclopentenyl C-nucleoside; antiviral agents; S(N)2 alkylation; ANTIVIRAL ACTIVITY; ENANTIOSELECTIVE SYNTHESIS; CARBOCYCLIC ANALOGS; 9-DEAZAADENOSINE; ANTITUMOR; CYTIDINE;

D O I：

10.1080/15257770902946058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel syntheses of 4-modified cyclopentenyl pyrimidine C-nucleosides were performed via C-C bond formation using S(N)2 alkylation via the key intermediate mesylates 6 and 16, which were prepared,from acyclic ketone derivatives. When antiviral evaluation of synthesized, compound was performed against various viruses such as HIV-1, HSV-1 and HSV-2, isocytidine analogue 20 showed, moderate anti-HIV activity in CEM cell line (EC50 = 13.1 mu mol).

引用

页码：303 / 314

页数：12

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