Discovery of SAM competitive and non-nucleoside derivative PRMT5 inhibitors with potent antitumor activity

被引:0
|
作者
Yang, Xiaozhi [1 ]
Zhou, Wei [2 ]
Li, Chenglong [1 ]
机构
[1] Univ Florida, Med Chem, Gainesville, FL USA
[2] Univ Florida, Gainesville, FL USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
80
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Discovery of SAM competitive, brain-restricted PRMT5 inhibitors with potent antitumor activity
    Tatlock, John
    Billitti, Joseph
    Braganza, John
    Brooun, Alexei
    Deng, Ya-Li
    Hirakawa, Brad
    Jensen-Pergakes, Kristen
    Kumpf, Robert
    Liu, Wei
    Maegley, Karen
    McAlpine, Indrawan
    McTigue, Michele
    Patman, Ryan
    Rui, Eugene
    Scales, Stephanie
    Tran-Dube, Michelle
    Wang, Fen
    Wang, Zhenxiong
    Yamazaki, Shinji
    Zhang, Tao
    Wythes, Martin
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [2] Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity
    Mcalpine, Indrawan J.
    Tatlock, John
    Billitti, Joseph
    Braganza, John
    Brooun, Alexei
    Deng Ya-Li
    Hirakawa, Brad
    Jensen-Pergakes, Kristen
    Kumpf, Robert
    Liu, Wei
    Maegley, Karen
    McTigue, Michele
    Patman, Ryan
    Rui, Eugene
    Scales, Stephanie
    Spiegel, Noah
    Tran-Dube, Michelle
    Wang, Fen
    Wang, Zhenxiong
    Yamazaki, Shinji
    Zhang, Tao
    Wythes, Martin
    CANCER RESEARCH, 2018, 78 (13)
  • [3] Discovery of Potent, Highly Selective, and Orally Bioavailable MTA Cooperative PRMT5 Inhibitors with Robust In Vivo Antitumor Activity
    Zhang, Meng
    Ding, Xiaoyu
    Cao, Zhongying
    Yang, Yilin
    Ding, Xiao
    Cai, Xin
    Zhang, Man
    Aliper, Alex
    Ren, Feng
    Lu, Hongfu
    Zhavoronkov, Alex
    JOURNAL OF MEDICINAL CHEMISTRY, 2025, 68 (02) : 1940 - 1955
  • [4] Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors
    Lin, Hong
    Wang, Min
    Zhang, Yang W.
    Tong, Shuilong
    Leal, Raul A.
    Shetty, Rupa
    Vaddi, Kris
    Luengo, Juan I.
    ACS MEDICINAL CHEMISTRY LETTERS, 2019, 10 (07): : 1033 - 1038
  • [5] The discovery and preclinical characterization of the SAM-competitive PRMT5 inhibitor UCT-000445
    McDermott, Martina S.
    O'Brien, Neil A.
    O'Boyle, Brendan
    Bartberger, Michael
    Loson, Oliver C.
    Chau, Kevin
    Schwab, Ella
    Hong, Jenny
    Zhou, Jiaying
    Hu, Chuhong
    Luo, Tong
    Ayala, Raul
    Glasby, John
    Stoltz, Brian M.
    Slamon, Dennis J.
    CANCER RESEARCH, 2023, 83 (07)
  • [6] Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors
    Lin, Hong
    Luengo, Juan, I
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (11) : 1264 - 1269
  • [7] Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity
    Kongkai Zhu
    Jingwei Shao
    Hongrui Tao
    Xue Yan
    Cheng Luo
    Hua Zhang
    Wenhu Duan
    Journal of Computer-Aided Molecular Design, 2019, 33 : 775 - 785
  • [8] Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity
    Zhu, Kongkai
    Shao, Jingwei
    Tao, Hongrui
    Yan, Xue
    Luo, Cheng
    Zhang, Hua
    Duan, Wenhu
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 33 (08) : 775 - 785
  • [9] Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues
    Talukdar, Arindam
    Mukherjee, Ayan
    Bhattacharya, Debomita
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (03) : 1662 - 1684
  • [10] Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors
    Chen, Yuting
    Shi, Qiongyu
    Yang, Hong
    Li, Jiayi
    Zhou, Kaixin
    Zhang, Junjie
    Wang, Zekun
    Shi, Huanyu
    Xiong, Bing
    Liu, Jia
    Huang, Xun
    Liu, Tongchao
    BIOORGANIC CHEMISTRY, 2023, 130