Development of a Non-Invasive Diagnostic Method for Bronchial Asthma

被引：0

作者：

Syslova, Kamila ^{[1
]}

Prech, Jan ^{[1
]}

Lebedova, Jindriska ^{[2
,3
]}

Pelclova, Daniela ^{[2
,3
]}

Kacer, Petr ^{[1
]}

机构：

[1] Inst Chem Technol, Ustav Organ Technol, Dept Organ Technol, CR-16628 Prague 6, Czech Republic

[2] Charles Univ Prague, Klin Nemoci & Povolani, Lekarska Fak 1, Prague 12000 2, Czech Republic

[3] Charles Univ Prague, Fac Med 1, Dept Occupat Med, Prague 12000 2, Czech Republic

来源：

CHEMICKE LISTY | 2009年 / 103卷 / 03期

关键词：

EXHALED BREATH CONDENSATE; CYSTEINYL-LEUKOTRIENES; 8-ISOPROSTANE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method was developed for rapid and accurate determination of cysteinylleukotrienes (LTC4, LTD4, LTE4 essential biomarkers of bronchial asthma, in exhaled breath condensate. The method consists of an immunoseparation procedure combined with selective and sensitive detection by LC-ESI-MS in the multiple reaction monitoring mode (MRM) and using a stable-isotope-dilution assay. The precision of the method was around 94%. The mean accuracy was higher than 90% for the content of cysteinylleukotrienes in the concentrate up to 250 pg ml(-1). The method was tested on patients with occupational bronchial asthma and compared with healthy subjects. The differences between the two groups were significant.

引用

页码：224 / 231

页数：8

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