Diffusion Properties of the Ternary System Human Serum Albumin-Sodium Cholate-Water

被引:0
|
作者
D'Errico, G. [1 ,2 ]
Ortona, O. [1 ]
Paduano, L. [1 ,2 ]
Sartorio, R. [1 ]
机构
[1] Univ Naples Federico II, Dept Sci Chim, I-80126 Naples, Italy
[2] CCSS Ctr Colloid & Surface Sci, CSGI Consorzio Interuniv Sviluppo Sistemi & Grand, I-80126 Naples, Italy
基金
美国国家航空航天局;
关键词
Mutual diffusion coefficients; Nernst-Hartley equations; Binding equilibrium; Excluded volume effect; PROTEIN CRYSTAL-GROWTH; PLUS ACETIC-ACID; DRUG BINDING-SITES; MULTICOMPONENT DIFFUSION; MUTUAL DIFFUSION; AQUEOUS-SOLUTIONS; BILE-SALTS; POLY(ETHYLENE GLYCOL); 3-COMPONENT SYSTEMS; LYSOZYME CHLORIDE;
D O I
10.1007/s10953-014-0179-y
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The four diffusion coefficients of the ternary system human serum albumin (HSA,1)-sodium cholate (NaC,2)-water (W, 0) were determined at three average compositions with constant protein concentration, C-1 degrees, and variable bile salt concentration, C-2. Various types of solute-solute interactions are present in this ternary system: electrostatic, co-ions-protein, and unspecific volume interactions due to the large difference in size of the two solutes. Each type of interaction has a different effect in determining the values and the sign of the experimental diffusion coefficients, D-exp(ij). To simplify the analysis of the dependence of the D-exp(ij) s on C-2, we considered three model systems where different types of solute-solute interaction are present individually. The overall analysis allows highlighting which kinds of solute-solute interaction predominates in determining the value of each diffusion coefficient.
引用
收藏
页码:893 / 915
页数:23
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