Enantioselective synthesis of indolizidine and quinolizidine derivatives from chiral non-racemic bicyclic lactams

被引：40

作者：

Agami, C ^{[1
]}

Dechoux, L ^{[1
]}

Hebbe, S ^{[1
]}

Ménard, C ^{[1
]}

机构：

[1] Univ Paris 06, Lab Synth Asymetr, UMR 7611, F-75005 Paris, France

来源：

TETRAHEDRON | 2004年 / 60卷 / 25期

关键词：

bicyclic lactams; lupinine; epitashiromine; quinolizidine; indolizidine;

D O I：

10.1016/j.tet.2004.04.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral non-racemic bicyclic lactams 2b,c, derived from (R)- and (S)-phenylglycinol, were used in the enantioselective synthesis of (-)-lupinine and 5 -epitashiromine, respectively. The efficiency of the synthesis relied on the high diastereoselectivities of formation and reduction of compounds 2b,c. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5433 / 5438

页数：6

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