The New Plant Expression System for the Development of Vaccines against Papillomaviruses

被引：5

作者：

Salyaev, R. K. ^{[1
]}

Rekoslavskaya, N., I ^{[1
,2
]}

Stolbikov, A. S. ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Siberian Inst Plant Physiol & Biochem, Irkutsk 664033, Russia

[2] Russian Acad Sci, Siberian Branch, Irkutsk Sci Ctr, Irkutsk 664033, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2019年 / 484卷 / 01期

关键词：

HEPATITIS-B; VIRUS; IMMUNOGENICITY; MICE;

D O I：

10.1134/S1607672919010150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To enhance the synthesis of antigenic envelope proteins L1 of high-grade papillomavirus types HPV16, HPV18, HPV31, and HPV45, the sequence of the gene encoding the cucumber mosaic virus replicase (RdRP CMV) was inserted into the genetic construct. This made it possible to increase the production of these antigenic proteins to 25-27 g/mg total soluble protein.

引用

页码：52 / 54

页数：3

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