DFU, a selective COX-2 inhibitor, suppresses MCF-7 xenograft tumor growth in mice

被引：0

作者：

Matsumoto, G ^{[1
]}

Rahman, MA ^{[1
]}

Muta, M ^{[1
]}

Nakamura, T ^{[1
]}

Bando, H ^{[1
]}

Saji, S ^{[1
]}

Tsuruta, K ^{[1
]}

Okamoto, A ^{[1
]}

Toi, M ^{[1
]}

机构：

[1] Tokyo Metropolitan Komagome Hosp, Dept Surg, Bunkyo Ku, Tokyo 1138677, Japan

来源：

ONCOLOGY REPORTS | 2004年 / 12卷 / 02期

关键词：

cyclooxygenase-2; DFU; breast cancer;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyclooxygenase-2 (COX-2) inhibitors are regarded as potentially important in strategies for cancer treatment. However, the precise mechanisms of these anti-inflammatory drugs as anti-cancer therapy are still unknown. In this study, we examined the effect of DFU both in vitro on MCF-7 cell growth, as well as in vivo on tumor growth produced by MCF-7 cell injection in mice. DFU has growth inhibitory effects on tumor growth in mice compared to the control group. We examined the tumor tissues for apoptosis and angiogenesis by immunostaining. Apoptosis was detected only in the treatment group. DFU treatment also resulted in the inhibition of angiogenesis, as well as decreased COX-2 expression. Results of this study suggest that inhibitory effects of DFU might be COX-2 dependent.

引用

页码：281 / 285

页数：5

共 50 条

[1] Choosing the Right Protocol to Establish MCF-7 Tumor Xenograft in Nude Mice
Behzadi, Ramezan
Ahmadpour, Sajjad
Amiri, Fereshteh Talebpour
Kavosian, Saeid
Asori, Mohsen
Hosseinimehr, Seyed Jalal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2023, 23 (02) : 222 - 226
[2] The selective Cox-2 inhibitor Celecoxib suppresses angiogenesis and growth of secondary bone tumors: An intravital microscopy study in mice
Klenke, FM
Gebhard, MM
Ewerbeck, V
Abdollahi, A
Huber, PE
Sckell, A
BMC CANCER, 2006, 6 (1)
[3] The selective Cox-2 inhibitor Celecoxib suppresses angiogenesis and growth of secondary bone tumors: An intravital microscopy study in mice
Frank Michael Klenke
Martha-Maria Gebhard
Volker Ewerbeck
Amir Abdollahi
Peter E Huber
Axel Sckell
BMC Cancer, 6
[4] COX-2 inhibitor celecoxib suppresses tumor growth and lung metastasis of a murine mammary cancer
Yoshinaka, Ryoji
Shibata, Masa-Aki
Morimoto, Junji
Tanigawa, Nobuhiko
Otsuki, Yoshinori
ANTICANCER RESEARCH, 2006, 26 (6B) : 4245 - 4254
[5] Rapid tumor development with a modified MCF-7 xenograft model
Hale, LV
Layman, NK
Wilson, P
Short, LL
Magee, DE
Wightman, SR
FuchsYoung, R
LABORATORY ANIMAL SCIENCE, 1997, 47 (01): : 82 - 85
[6] Proteins from Lignosus tigris with selective apoptotic cytotoxicity towards MCF7 cell line and suppresses MCF7-xenograft tumor growth
Kong, Boon Hong
Teoh, Kean Hooi
Tan, Nget Hong
Tan, Chon Seng
Ng, Szu Ting
Fung, Shin Yee
PEERJ, 2020, 8
[7] Rofecoxib: A selective COX-2 inhibitor
不详
Drugs & Therapy Perspectives, 2000, 15 (2) : 1 - 5
[8] Linalool Inhibits MCF-7 Tumor Growth in a Xenograft Model by Apoptosis Induction and Immune Modulation
Zhao, Yunqi
Meng, Xi
Zeng, Yan
Wang, Canbin
Chen, Jiwei
She, Zhennan
NATURAL PRODUCT COMMUNICATIONS, 2021, 16 (05)
[9] Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models
Kato, Yoshinori
Okollie, Baosil
Raman, Venu
Vesuna, Farhad
Zhao, Ming
Baker, Sharyn D.
Bhuiwalla, Zaver M.
Artemov, Dmitri
CANCER BIOLOGY & THERAPY, 2007, 6 (06) : 891 - 897
[10] Estradiol induces cell proliferation in MCF-7 mammospheres through HER2/COX-2
Wu, Chin-Hu
Chuang, Hui-Yu
Wang, Chiu-Lin
Hsu, Chia-Yi
Long, Cheng-Yu
Hsieh, Tsung-Hua
Tsai, Eing-Mei
MOLECULAR MEDICINE REPORTS, 2019, 19 (03) : 2341 - 2349

← 1 2 3 4 5 →