Increased cyclooxygenase-2, hyperfiltration, glomerulosclerosis, and diabetic nephropathy: put the blame on the (pro) renin receptor?

被引：31
|
作者：
Nguyen, G.
机构：
[1] INSERM, Unit 36, F-75005 Paris, France
[2] Coll France, Expt Med Unit, F-75005 Paris, France
来源：
KIDNEY INTERNATIONAL | 2006年 / 70卷 / 04期
关键词：
D O I：
10.1038/sj.ki.5001723
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Interaction between the renin-angiotensin system and cyclooxygenases in the kidney regulates renal microcirculation. Activation of the (pro) renin receptor has profibrotic effects, and now Kaneshiro et al. show that it also increases COX-2 synthesis. These results may have therapeutic implications, as blocking (pro) renin receptor interaction would prevent the increase of angiotensin generation and prostaglandin synthesis, two phenomena underlying the pathogenesis of diabetic nephropathy.
引用
收藏
页码：618 / 620
页数：5
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