Increased Th17 cells and IL-17 in rats with traumatic optic neuropathy

被引：16
|
作者：
Zheng, Huabin [1 ]
Zhang, Zhuhong [1 ]
Luo, Na [2 ]
Liu, Yuanyuan [1 ]
Chen, Qingzhong [1 ]
Yan, Hua [1 ]
机构：
[1] Tianjin Med Univ, Gen Hosp, Dept Ophthalmol, Tianjin 300052, Peoples R China
[2] Nankai Univ, Sch Med, Dept Immunol, Tianjin 300071, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2014年 / 10卷 / 04期
关键词：
traumatic optic neuropathy; T helper 17 cells; interleukin-17; retina; optic nerve; REGULATORY T-CELLS; DISEASE; INJURY; AUTOIMMUNITY;
D O I：
10.3892/mmr.2014.2448
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
T helper 17 (Th17) cells are strong inducers of numerous autoimmune diseases and inflammation. However, the role of Th17 cells and interleukin (IL)-17 in traumatic optic neuropathy (TON) are yet to be elucidated. In the present study, a rat model of TON was established using a fluid percussion brain injury device. Th17 cells were found to be upregulated in the spleens of rats in the TON group. In addition, the level of IL-17 in the retina of rats in the TON group was observed to increase with the upregulation of the Th17 cells. Furthermore, the expression of IL-17 in the optic nerve was found to be upregulated between one and seven days following injury in the rats in the TON group. These findings strongly suggest that the ratio of Th17 cells and the expression of IL-17 are upregulated in rats with TON. These findings also provide a rationale for developing therapeutic agents to treat TON.
引用
收藏
页码：1954 / 1958
页数：5
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