Transfer of blastocysts and morulae on day 5

被引:25
|
作者
Wilson, M [1 ]
Hartke, K [1 ]
Kiehl, M [1 ]
Rodgers, J [1 ]
Brabec, C [1 ]
Lyles, R [1 ]
机构
[1] Reprod Resource Ctr Greater Kansas City, Overland Pk, KS 66215 USA
关键词
IVF; embryo culture; blastocysts; morulae;
D O I
10.1016/j.fertnstert.2004.03.023
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To limit the number of embryos transferred and reduce high-order multiple pregnancies without compromising a patient's opportunity to become pregnant. Design: Retrospective, nonrandomized analysis of embryo development and patient outcome when embryos were transferred on day 5. Setting: Private practice. Patient(s): Women undergoing in vitro fertilization (IVF) treatment. Intervention(s): Extend embryo culture to day 5 before embryo transfer (ET) to reduce the number of embryos transferred and minimize high-order multiple pregnancies. Main Outcome Measure(s): Clinical pregnancy rate (CPR), implantation rate (IR), and live born rate (LBR) from expanding (expanded blastocysts and blastocysts) and nonexpanding (early blastocysts and morulae) embryos transferred on day 5. Result(s): Approximately 60% of patients had expanding embryos (EXE) on day 5. Forty percent of patients having an ET had transferable non-expanding embryos (NEE). Patients with EXE had higher CPR and LBR compared to patients with NEE. Implantation rate and multiple pregnancy rate (MPR) were also higher for patients with EXE. The miscarriage rate (MCR) for patients with EXE and NEE was not different. Approximately 5.5% of patients did not have an ET, with most (>98%) of the ET failures from patients with less than or equal to 3 two pronuclei (2PN) embryos. The number of 2PN embryos had an effect on CPR, LBR, MPR, and the number of patients having cryopreservation. Conclusion(s): Day 5 ET allows for the selection of embryos with the highest implantation potential as evidenced by acceptable pregnancy rates for patients with either EXE or NEE, without the need to transfer more than two embryos.
引用
收藏
页码:327 / 333
页数:7
相关论文
共 50 条
  • [21] CONVERSION OF PREGNENOLONE TO PROGESTERONE BY MOUSE MORULAE AND BLASTOCYSTS
    WU, JT
    LIU, ZH
    JOURNAL OF REPRODUCTION AND FERTILITY, 1990, 88 (01): : 93 - 98
  • [22] GLUCOSE METABOLISM IN RABBIT OVA, MORULAE, AND BLASTOCYSTS
    FRIDHANDLER, L
    FEDERATION PROCEEDINGS, 1959, 18 (01) : 48 - 48
  • [23] Day 5 vs. day 6: A comparison between fresh and frozen blastocysts transfer cycles
    Zaninovic, N
    Veeck, LL
    Bodine, R
    Clarke, R
    Manheim, E
    Rosenwaks, Z
    FERTILITY AND STERILITY, 2004, 82 : S225 - S225
  • [24] FUSION OF RAT AND MOUSE MORULAE AND FORMATION OF CHIMAERIC BLASTOCYSTS
    ZEILMAKER, GH
    NATURE, 1973, 242 (5393) : 115 - 116
  • [25] DAY 5 BLASTOCYSTS CONTAIN HIGHER MITOCHONDRIAL DNA CONTENT COMPARED TO DAY 6 BLASTOCYSTS
    Klimczak, Amber M.
    Vaughn, Micah
    Nutter, Anna
    Richards, Jon P.
    Kearns, William G.
    Saad, Antonio F.
    Crochet, John R.
    FERTILITY AND STERILITY, 2018, 109 (03) : E32 - E33
  • [26] DEVELOPMENTAL CAPACITY OF MECHANICALLY BISECTED MOUSE MORULAE AND BLASTOCYSTS
    WANG, ZJ
    TROUNSON, A
    DZIADEK, M
    REPRODUCTION FERTILITY AND DEVELOPMENT, 1990, 2 (06) : 683 - 691
  • [27] Perinatal outcomes following transfer of human blastocysts vitrified at day 5, 6 and 7
    Hiraoka, K.
    Hiraoka, K.
    Miyazaki, M.
    Fukunaga, E.
    Horiuchi, T.
    Kusuda, T.
    Okano, S.
    Kinutani, M.
    Kinutani, K.
    HUMAN REPRODUCTION, 2010, 25 : I60 - I60
  • [28] Comparison of transfer outcomes using thawed day 3 preembryos and thawed day 5/6 blastocysts.
    Veeck, LL
    Bodine, R
    Clarke, RN
    Berrios, R
    Urcia, E
    Rosenwaks, Z
    FERTILITY AND STERILITY, 2002, 78 (03) : S275 - S275
  • [29] Fine structure of bovine morulae and blastocysts in vivo and in vitro
    Abe, H
    Otoi, T
    Tachikawa, S
    Yamashita, S
    Satoh, T
    Hoshi, H
    ANATOMY AND EMBRYOLOGY, 1999, 199 (06): : 519 - 527
  • [30] Fine structure of bovine morulae and blastocysts in vivo and in vitro
    H. Abe
    T. Otoi
    S. Tachikawa
    S. Yamashita
    T. Satoh
    H. Hoshi
    Anatomy and Embryology, 1999, 199 : 519 - 527