Knockdown of LncRNA RHPN1-AS1 Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma

被引：27
|
作者：
Qiu, Xiaowen [1 ,2 ]
Lei, Zhuo [3 ,4 ]
Wang, Zeyou [5 ]
Xu, Yuming [1 ]
Liu, Chang [1 ]
Li, Panchun [1 ]
Wu, Hanjiang [1 ]
Gong, Zhaojian [1 ]
机构：
[1] Cent S Univ, Xiangya Hosp 2, Dept Stomatol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[2] Haikou Peoples Hosp, Dept Stomatol, Haikou 570208, Hainan, Peoples R China
[3] Cent S Univ, Xiangya Stomatol Hosp, Changsha 410008, Hunan, Peoples R China
[4] Cent S Univ, Sch Stomatol, Changsha 410008, Hunan, Peoples R China
[5] Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China
来源：
JOURNAL OF CANCER | 2019年 / 10卷 / 17期
基金：
中国国家自然科学基金;
关键词：
Long non-coding RNA; RHPN1-AS1; HNSCC; EMT; LONG NONCODING RNA; TRANSCRIPTIONAL NOISE; MODULAR SCAFFOLD; CANCER; PROMOTES; EXPRESSION; PROGRESSION; EMT; METASTASIS; PREDICTS;
D O I：
10.7150/jca.29029
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Previous studies have revealed that long non-coding RNAs (lncRNAs) are involved in head and neck squamous cell carcinoma (HNSCC) progression. However, the detailed roles of lncRNA RHPN1-AS1 remain to be elucidated. In this study, by analyzing online RNA-Seq data, we found that RHPN1-AS1 was upregulated in HNSCC tissues and that its expression level was associated with neoplasm histologic grade. High expression of RHPN1-AS1 was also confirmed in HNSCC tissues. Knockdown of RHPN1-AS1 inhibited tumor cell migration, invasion and proliferation in HNSCC. Furthermore, inhibition of RHPN1-AS1 suppressed the expression of epithelial-mesenchymal transition (EMT)-related genes (beta-Catenin, Claudin-I and Vimentin) in HNSCC cells. Collectively, our results suggest that RHPN1-AS1, acting as an oncogene, may be a potential diagnostic and therapeutic target in HNSCC.
引用
收藏
页码：4000 / 4008
页数：9
相关论文
共 50 条
  • [1] lncRNA TPT1-AS1 knockdown inhibits liver cancer cell proliferation, migration and invasion
    Li, Hao
    Jin, Jing
    Xian, Jianchun
    Wang, Wei
    MOLECULAR MEDICINE REPORTS, 2021, 24 (05)
  • [2] Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma
    Ye, Min
    Wu, Qundan
    Zhang, Min
    Huang, Jinbei
    MOLECULAR MEDICINE REPORTS, 2016, 14 (04) : 2953 - 2958
  • [3] Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells
    Liu, Lifeng
    Zhang, Pengfei
    Shao, Yuan
    Quan, Fang
    Li, Huajing
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (09) : 15874 - 15882
  • [4] Knockdown of NDUFC1 inhibits cell proliferation, migration, and invasion of hepatocellular carcinoma
    Han, Fang
    Liu, Junwei
    Chu, Hongwu
    Cao, Dan
    Wu, Jia
    Fu, Hong
    Guo, Anyang
    Chen, Weiqin
    Xu, Yingping
    Cheng, Xiangdong
    Zhang, Yuhua
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [5] Endostatin inhibits migration and invasion of head and neck squamous cell carcinoma cells
    Wilson, RF
    Morse, MA
    Pei, P
    Renner, RJ
    Schuller, DE
    Robertson, FM
    Mallery, SR
    ANTICANCER RESEARCH, 2003, 23 (2B) : 1289 - 1295
  • [6] Fra-1 promotes cell invasion and migration of head and neck squamous cell carcinoma
    Sawakuma, Kae
    Sano, Daisuke
    Hatano, Takashi
    Hyakusoku, Hiroshi
    Isono, Yasuhiro
    Shimada, Shoko
    Takada, Kentaro
    Oridate, Nobuhiko
    CANCER SCIENCE, 2018, 109 : 318 - 318
  • [7] LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma
    Wei Zhang
    Lei Han
    Peng Xing
    Bailiang Liu
    Zhongqi Sun
    Wenping Zhou
    Jiahong Dong
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 393 : 2543 - 2551
  • [8] FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation
    Hyakusoku, Hiroshi
    Sawakuma, Kae
    Sano, Daisuke
    Takahashi, Hideaki
    Hatano, Takashi
    Sato, Kaname
    Isono, Yasuhiro
    Shimada, Shoko
    Takada, Kentaro
    Kuwahara, Tatsu
    Aizawa, Yoshihiro
    Oridate, Nobuhiko
    ANTICANCER RESEARCH, 2021, 41 (07) : 3317 - 3326
  • [9] LncRNA RHPN1-AS1 Targeting miR-625/REG3A Promotes Cell Proliferation And Invasion Of Glioma Cells
    Cui, Peng
    Su, Jichun
    Li, Qingmin
    Xu, Guangming
    Zhu, Ningxi
    ONCOTARGETS AND THERAPY, 2019, 12 : 7911 - 7921
  • [10] LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma
    Mang, Wei
    Han, Lei
    Xing, Peng
    Liu, Bailiang
    Sun, Zhongqi
    Zhou, Wenping
    Dong, Jiahong
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2020, 393 (12) : 2543 - 2551
12345