Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead

被引：29
|
作者：
Colao, Annamaria [1 ]
de Nigris, Filomena [2 ]
Modica, Roberta [3 ]
Napoli, Claudio [4 ]
机构：
[1] Federico II Univ Naples, Dept Clin Med & Surg, Unesco Chair Hlth Educ & Sustainable Dev, Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Precis Med, Naples, Italy
[3] Federico II Univ Naples, Dept Clin Med & Surg, Naples, Italy
[4] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy
来源：
FRONTIERS IN ENDOCRINOLOGY | 2020年 / 11卷
关键词：
epigenetics; neuroendocrine neoplasms; trials; biomarkers; neuroendocrine; neuroendocrine tumor; CIRCULATING TRANSCRIPT ANALYSIS; DNA METHYLATION; PANCREATIC ENDOCRINE; MICRORNA EXPRESSION; PROGNOSTIC RELEVANCE; GERMLINE MUTATION; CARCINOID-TUMORS; DOWN-REGULATION; THERAPY; CANCER;
D O I：
10.3389/fendo.2020.604341
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neuroendocrine tumors, or NETs, are cancer originating in neuroendocrine cells. They are mostly found in the gastrointestinal tract or lungs. Functional NETs are characterized by signs and symptoms caused by the oversecretion of hormones and other substances, but most NETs are non-functioning and diagnosis in advanced stages is common. Thus, novel diagnostic and therapeutic strategies are warranted. Epigenetics may contribute to refining the diagnosis, as well as to identify targeted therapy interfering with epigenetic-sensitive pathways. The goal of this review was to discuss the recent advancement in the epigenetic characterization of NETs highlighting their role in clinical findings.
引用
收藏
页数：12
相关论文
共 50 条
  • [1] Clinical applications of epigenetics in cardiovascular disease: the long road ahead
    Aslibekyan, Stella
    Claas, Steven A.
    Arnett, Donna K.
    TRANSLATIONAL RESEARCH, 2015, 165 (01) : 143 - 153
  • [2] Epigenetics of Host-Pathogen Interactions: The Road Ahead and the Road Behind
    Gomez-Diaz, Elena
    Jorda, Mireia
    Angel Peinado, Miguel
    Rivero, Ana
    PLOS PATHOGENS, 2012, 8 (11)
  • [3] Epigenetics of gastroenteropancreatic neuroendocrine tumors: A clinicopathologic perspective
    Brendan M Finnerty
    Katherine D Gray
    Maureen D Moore
    Rasa Zarnegar
    Thomas J Fahey Ⅲ
    World Journal of Gastrointestinal Oncology, 2017, (09) : 341 - 353
  • [4] Epigenetics of gastroenteropancreatic neuroendocrine tumors: A clinicopathologic perspective
    Finnerty, Brendan M.
    Gray, Katherine D.
    Moore, Maureen D.
    Zarnegar, Rasa
    Fahey, Thomas J., III
    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2017, 9 (09) : 341 - 353
  • [5] Genetics and Epigenetics of Pancreatic Neuroendocrine Tumors and Pulmonary Carcinoids
    Dreijerink, Koen M. A.
    Derks, Jules L.
    Cataldo, Ivana
    Scarpa, Aldo
    Valk, Gerlof D.
    Speel, Ernst-Jan M.
    NEUROENDOCRINE TUMORS: A MULTIDISCIPLINARY APPROACH, 2015, 44 : 115 - 138
  • [6] Therapeutic Monitoring of Gastroenteropancreatic Neuroendocrine Tumors: The Challenges Ahead
    Sundin, Anders
    Rockall, Andrea
    NEUROENDOCRINOLOGY, 2012, 96 (04) : 261 - 271
  • [7] Editorial: Neuroendocrine tumors: the road to precision medicine
    La Salvia, Anna
    Giuffrida, Dario
    Modica, Roberta
    FRONTIERS IN ENDOCRINOLOGY, 2023, 14
  • [8] The road ahead in clinical network neuroscience
    Douw, Linda
    van Dellen, Edwin
    Gouw, Alida A.
    Griffa, Alessandra
    de Haan, Willem
    van den Heuvel, Martijn
    Hillebrand, Arjan
    Van Mieghem, Piet
    Nissen, Ida A.
    Otte, Willem M.
    Reijmer, Yael D.
    Schoonheim, Menno M.
    Senden, Mario
    van Straaten, Elisabeth C. W.
    Tijms, Betty M.
    Tewarie, Prejaas
    Stam, Cornelis J.
    NETWORK NEUROSCIENCE, 2019, 3 (04): : 969 - 993
  • [9] Clinical genetics of neuroendocrine tumors
    Karges, W
    Adler, G
    MEDIZINISCHE KLINIK, 2003, 98 (12) : 712 - 716
  • [10] Pancreatic neuroendocrine tumors:: how far have we gone ahead?
    Villaverde, RM
    Barón, MG
    REVISTA CLINICA ESPANOLA, 2002, 202 (05): : 269 - 271
12345