The Phox (PX) domain proteins and membrane traffic

被引：159

作者：

Seet, Li-Fong ^{[1
]}

Hong, Wanjin ^{[1
]}

机构：

[1] Inst Mol & Cell Biol, Membrane Biol Lab, Proteos, Singapore 138673, Singapore

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2006年 / 1761卷 / 08期

关键词：

PX domain; phosphoinositide; lipid; endosome; membrane targeting; membrane traffic; endocytosis;

D O I：

10.1016/j.bbalip.2006.04.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphoinositides (PIs) are phosphorylated derivatives of phosphatidylinositol (PtdIns) that regulate many cellular and physiological processes. Most PIs act by serving as membrane docking sites for proteins harboring specific PI-binding domains so that the location and function of these proteins could be dynamically governed. The Phox (PX) domain represents a novel PI-binding module capable of regulating membrane targeting of about 47 mammalian proteins, 30 of which are tentatively referred to as sorting nexins (SNXs). Some SNXs have been implicated in regulating membrane trafficking in the endocytic pathway. We discuss here recent development and progress in the study of the PX domain-containing proteins. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：878 / 896

页数：19

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