Cytochrome P450 epoxygenases as EDHF synthase(s)

被引：115
|
作者：
Fleming, I [1 ]
机构：
[1] Goethe Univ Frankfurt, Inst Kardiovaskulare Physiol, D-60590 Frankfurt, Germany
来源：
PHARMACOLOGICAL RESEARCH | 2004年 / 49卷 / 06期
关键词：
angiogenesis; calcium-dependent potassium channels epoxyeicosatrienoic acids; gap junctions; soluble epoxide hydrolase;
D O I：
10.1016/j.phrs.2003.11.016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca2+ signaling and the activity of Ca2+-dependent K+ channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is not constitutive but is determined by a number of physical (fluid shear stress and cyclic stretch) and pharmacological stimuli which also affect responses attributed to an endothelium-derived hyperpolarizing factor (EDHF). This review summarizes the role played by EETs, and the enzymes that generate and metabolize them, in EDHF-mediated responses. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：525 / 533
页数：9
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