On the basis of the G-point, defined as the center of the largest circle that is tangent to the internal inferior, anterior, and lingual surfaces of the mandibular symphysis in the sagittal view, a growth axis and its direction are described for each gender from age six to 19.25 years. Incremental growth along the G-Axis, defined by Sella-G-point, is described by regression formulas with correlation coefficients of 0.673 for female subjects and 0.749 for male subjects. The vector (direction) of the growth axis, defined by the angle alpha {(G-Axis)-(S-N)} does not materially alter in the age range studied. At age six in female subjects the angle alpha is 67.16degrees +/- 3.03degrees and at age 19.25 it is 66.87degrees +/- 3.03degrees, whereas in male subjects it is 66.12degrees +/- 4.00degrees and 67.93degrees +/- 4.00degrees, respectively. These changes and gender differences are not clinically significant. The data is based on 444 serial lateral cephalograms of 24 female subjects and 24 male subjects. The G-Axis incremental growth change and its vector offer an improved means of quantifying complex mandibular growth in the sagittal plane by using cephalometric measurements relative to and correlated with other craniofacial structures.