2,4,6-trichloropyrimidine. Reaction with sodium amide

被引：8
|
作者：
Delia, TJ [1 ]
Meltsner, BR [1 ]
Schomaker, JM [1 ]
机构：
[1] Cent Michigan Univ, Dept Chem, Malcolm H Filson Labs, Mt Pleasant, MI 48859 USA
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1999年 / 36卷 / 05期
关键词：
D O I：
10.1002/jhet.5570360524
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first reaction between 2,4,6-trichloropyrimidine 1 and anionic nitrogen nucleophiles is described. Treatment of 1 with one equivalent of sodium amide gave mixtures of 4-amino-2,6-dichloropyrimidine 2 and 2-amino-4,6-dichloropyrimidine 3. Additional quantities of sodium amide failed to provide either diamino- or triaminopyrimidines. Instead, the strongly basic nature of sodium amide led to higher molecular products that were not characterized.
引用
收藏
页码：1259 / 1261
页数：3
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