Curcumin Inhibits MHCC97H Liver Cancer Cells by Activating ROS/TLR-4/Caspase Signaling Pathway

被引：41

作者：

Li, Pei-Min ^{[1
]}

Li, Yu-Liang ^{[2
]}

Liu, Bin ^{[2
]}

Wang, Wu-Jie ^{[2
]}

Wang, Yong-Zheng ^{[2
]}

Li, Zheng ^{[2
]}

机构：

[1] Changzhi Med Coll, Heping Hosp, Dept Radiol, Changzhi, Peoples R China

[2] Shandong Univ, Hosp 2, Dept Intervent Therapy, Jinan 250100, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2014年 / 15卷 / 05期

关键词：

Curcumin; liver cancer; reactive oxygen species; toll-like receptor 4; apoptosis; TUMOR-CELLS; HEPATOCELLULAR-CARCINOMA; APOPTOSIS PATHWAYS; DOWN-REGULATION; OVARIAN-CANCER; IN-VITRO; DEATH; INDUCTION; EXPRESSION; ANTICANCER;

D O I：

10.7314/APJCP.2014.15.5.2329

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Curcumin can inhibit proliferation of liver cancer cells by inducing apoptosis, but the specific signaling pathways involved are not completely clear. Here, we report that curcumin inhibited proliferation of MHCC97H liver cancer cells by induction of apoptosis in a concentration dependent manner via stimulating intracellular reactive oxygen species (ROS) generation. Also, we showed that increased intracellular ROS formation activated the TLR-4/MyD-88 signaling pathway, resulting in activation of caspase-8 and caspase-3, which eventually led to apoptosis in MHCC97H cells. These results showed that as an prooxidant, curcumin exerts anti-cancer effects by inducing apoptosis via the TLR-4/MyD-88 signaling pathway.

引用

页码：2329 / 2334

页数：6

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