Influences of Selenium on the Duckling Hepatic Mitochondrial Membrane Permeability Changes Induced by Aflatoxin B1

In order to observe the influences of aflatoxin B-1 (AFBI) on hepatic mitochondrial membrane permeability in ducklings and study the antagonistic effect of sodium selenite (Na2SeO3) on AFBI. Seven day-old ducklings were used as experimental animals. All animals were divided into three groups (30 animals each). The ducklings of group I was fed on the same volume of DMSO only with the other group as control. Group II, III were administered intragastrically AFB(1) at a dose 0.1mg/kg body weight respectively, and group HI was fed on sodium selenite at a dose 1mg/kg. All treatments were given once daily during 7-28 day-old. The duckling hepatic mitochondrial membrane permeability was detected on 7th, 14th, 21th day after treatment. The results showed that the ducklings hepatic mitochondrial membrane permeability in AFBI treated ducklings (Group II, III) was higher than group I (P < 0.05), and the hepatic mitochondrial membrane permeability of group II was higher than sodium selenite treated group (group III) (P < 0.05). These results revealed that sodium selenite could ameliorate the duckling hepatic mitochondrial membrane permeability changes induced by aflatoxin B-1.