Insulin Therapy and Type 2 Diabetes: Management of Weight Gain

被引：32
|
作者：
McFarlane, Samy I. [1 ]
机构：
[1] SUNY, Div Endocrinol, Coll Med, Downstate & Kings Cty Med Ctr, Brooklyn, NY 11203 USA
来源：
JOURNAL OF CLINICAL HYPERTENSION | 2009年 / 11卷 / 10期
关键词：
NPH INSULIN; GLYCEMIC CONTROL; DETEMIR; RESISTANCE; GLUCOSE; MELLITUS; RISK; INITIATION; APPETITE; DRUGS;
D O I：
10.1111/j.1751-7176.2009.00063.x
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The potential for insulin-related weight gain in patients with type 2 diabetes presents a therapeutic dilemma and frequently leads to delays in the initiation of insulin therapy. It also poses considerable challenges when treatment is intensified. Addressing insulin-related weight gain is highly relevant to the prevention of metabolic and cardiovascular consequences in this high-risk population with type 2 diabetes. In addition to lifestyle changes (eg, diet and exercise) and available medical interventions to minimize the risk of weight gain with insulin treatment, familiarity with the weight gain patterns of different insulins may help deal with this problem. The use of basal insulin analogs may offer advantages over conventional human insulin preparations in terms of more physiologic time-action profiles, reduced risk of hypoglycemia, and reduced weight gain.
引用
收藏
页码：601 / 607
页数：7
相关论文
共 50 条
  • [1] Insulin therapy in type 2 diabetes and weight gain in the short term
    Hmida, C.
    DIABETES & METABOLISM, 2009, 35 : A67 - A68
  • [2] Weight gain during insulin therapy in patients with type 2 diabetes mellitus
    Heller, S
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2004, 65 : S23 - S27
  • [3] Insulin therapy does not itself induce weight gain in patients with type 2 diabetes
    Larger, E
    Rufat, P
    Dubois-Laforgue, D
    Ledoux, S
    DIABETES CARE, 2001, 24 (10) : 1849 - 1850
  • [4] Insulin treatment and the problem of weight gain in type 2 diabetes
    Carver, Catherine
    DIABETES EDUCATOR, 2006, 32 (06): : 910 - 917
  • [5] Weight gain and fat distribution with pioglitazone in patients with type 2 diabetes on insulin therapy.
    Shah, P. K.
    Mudahar, S.
    Aroda, V.
    Wilson, J.
    Chao, E.
    Chang, A.
    Skouse, J.
    Burke, P.
    Andre, M.
    Henry, R. R.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2007, 55 (01) : S95 - S95
  • [6] Prevention of weight gain in type 2 diabetes requiring insulin treatment
    de Boer, H
    Jansen, M
    Koerts, J
    Verschoor, L
    DIABETES OBESITY & METABOLISM, 2004, 6 (02): : 114 - 119
  • [7] Long term insulin therapy in patients with type 2 Diabetes Mellitus induces an important weight gain
    Roman, Khaja S.
    Joseph, D. J.
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2010, 15 : 65 - 65
  • [8] A family history of type 2 diabetes predicts excess weight gain in subjects with type 1 diabetes on intensive insulin therapy in the DCCT
    Hokanson, JE
    Dev, RK
    Purnell, JQ
    Steffes, MW
    Cleary, PA
    Brunzell, JD
    DIABETES, 1999, 48 : A44 - A44
  • [9] Intensive Insulin Therapy in Youth with Type 1 Diabetes Is Not Associated with Untoward Weight Gain
    Laffel, Lori M. B.
    Volkening, Lisa K.
    Anderson, Barbara J.
    Weissberg-Benchell, Jill
    Wysocki, Tim
    Nansel, Tonja R.
    DIABETES, 2009, 58 : A460 - A460
  • [10] Uncoupling Intensive Insulin Therapy from Weight Gain and Hypoglycemia in Type 1 Diabetes
    Brown, Rebecca J.
    Wijewickrama, Rohan C.
    Harlan, David M.
    Rother, Kristina I.
    DIABETES TECHNOLOGY & THERAPEUTICS, 2011, 13 (04) : 457 - 460
12345