Enhanced in vitro activity of pyrimethamine in combination with dapsone against Mycobacterium avium complex

被引：4
|
作者：
Shah, LM
Meyer, SCC
Cynamon, MH
机构：
[1] VET AFFAIRS MED CTR,SYRACUSE,NY 13210
[2] SUNY SYRACUSE,HLTH SCI CTR,SYRACUSE,NY 13210
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 10期
关键词：
D O I：
10.1128/AAC.40.10.2426
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro activities of pyrimethamine and dapsone alone and in combination were evaluated against 23 clinical isolates of Mycobacterium avium complex. The broth dilution MICs of dapsone and pyrimethamine alone ranged from 16 to >64 mu g/ml. Pyrimethamine in combination crith a fixed concentration of dapsone at 0.5 mu g/ml showed enhanced activity, with an MIC range of 0.5 to 16 mu g/ml.
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收藏
页码：2426 / 2427
页数：2
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