The influence of intrinsic and extrinsic factors on immune system aging

被引：9
|
作者：
Badowski, Michael [1 ]
Shultz, Christopher L. [1 ]
Eason, Yvette [1 ]
Ahmad, Nafees [1 ]
Harris, David T. [1 ]
机构：
[1] Univ Arizona, Dept Immunobiol, Tucson, AZ 85724 USA
来源：
IMMUNOBIOLOGY | 2014年 / 219卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Aging; Immunity; OT-1; Mice; MCMV; T-CELLS; CD28; MICE; DIFFERENTIATION; SENESCENCE; EXPRESSION; PHENOTYPE;
D O I：
10.1016/j.imbio.2014.02.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57B1/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28(+) cells and an accumulation of KLRG1(+) T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8(+)28(-) and KLRG1(+) T cells with time. CD4(+) T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process. (C) 2014 Elsevier GmbH. All rights reserved.
引用
收藏
页码：482 / 485
页数：4
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