Evaluation of non-synonym mutation in DGAT1 K232A as a marker for milk production traits in Ongole cattle and Murrah buffalo from Southern India

被引:4
|
作者
Krovvidi, Sudhakar [1 ]
Thiruvenkadan, A. K. [2 ]
Murali, N. [2 ]
Saravanan, R. [2 ]
Vinoo, R. [1 ]
Metta, Muralidhar [1 ]
机构
[1] Sri Venkateswara Vet Univ, NTR Coll Vet Sci, Dept Anim Genet & Breeding, Gannavaram 521102, Andhra Pradesh, India
[2] Vet Coll & Res Inst, Dept Anim Genet & Breeding, Namakkal 637002, Tamil Nadu, India
关键词
DGAT1/K232A; Ongole cattle; Murrah buffalo; Milk yield; Milk composition; BREEDING VALUES; DAIRY-CATTLE; BOS-INDICUS; POLYMORPHISM; GENE; YIELD; DOMESTICATION; GHR; DNA;
D O I
10.1007/s11250-021-02560-2
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Various candidate genes have been reported to affect milk yield and composition in dairy cattle. A non-synonymous mutation in the DGAT1 gene, i.e., K232A was reported to have a strong association with milk yield and milk composition of Bos taurus. A study has been undertaken on 502 unrelated individuals belonging to indigenous Ongole cattle, crossbred cattle, and Murrah buffaloes from the Indian sub-continent with the objective to determine the polymorphism of the K232A locus and their association with milk yield and composition. Typing DGAT1 K232A allelic variation by PCR-RFLP using CfrI restriction enzyme revealed three genotypes in crossbred cattle. Genotype KK was more prevalent (0.60) in Jersey crossbred, whereas in Holstein Friesian crossbred it was KA genotype (0.48). In Ongole cattle and Murrah buffaloes, the locus did not exhibit polymorphism. The least-square mean of milk yields pooled over lactations across the DGAT1 variants was significantly (P < 0.05) higher among the homozygous (AA) genotypes, both in Jersey crossbred and HF crossbred cattle after adjusting for the effects of farm, parity, and season. The fat, SNF, and protein content values of AA genotypes were less than the KK genotypes in both the genetic groups (P > 0.05). The fixation of the DGAT1(K) allele at the locus in Bos indicus cattle and Bubalus bubalis in the present study did not support its use as a reliable universal marker for milk production and composition traits.
引用
收藏
页数:7
相关论文
共 16 条
  • [1] Evaluation of non-synonym mutation in DGAT1 K232A as a marker for milk production traits in Ongole cattle and Murrah buffalo from Southern India
    Sudhakar Krovvidi
    Muralidhar Thiruvenkadan A.K.
    Tropical Animal Health and Production, 2021, 53
  • [2] GENETIC PROFILING OF K232A MUTATION OF DGAT1 GENE IN MURRAH BUFFALO
    Kaur, Rajpal
    Magotra, Ankit
    Kumar, Sandeep
    Gera, Sandeep
    Karan, Ram
    Kamaldeep
    Garg, Asha
    Puspha
    BUFFALO BULLETIN, 2024, 43 (04): : 483 - 489
  • [3] DGAT1 K232A polymorphism is associated with milk production traits in Chinese cattle
    Li, Fangyu
    Cai, Cuicui
    Qu, Kaixing
    Liu, Jianyong
    Jia, Yutang
    Hanif, Quratulain
    Chen, Ningbo
    Zhang, Jicai
    Chen, Hong
    Huang, Bizhi
    Lei, Chuzhao
    ANIMAL BIOTECHNOLOGY, 2021, 32 (04) : 427 - 431
  • [4] Effect of the DGAT1 K232A mutation and breed on milk traits in cattle populations of Ethiopia
    Samuel, Behailu
    Dadi, Hailu
    Dinka, Hunduma
    FRONTIERS IN ANIMAL SCIENCE, 2023, 4
  • [5] Candidate K232A mutation of DGAT1 gene associated with production and reproduction traits in Indian diary cattle
    Gothwal, Anamika
    Magotra, Ankit
    Bangar, Yogesh C.
    Malik, B. S.
    Yadav, Abhay Singh
    Garg, Asha Rani
    ANIMAL BIOTECHNOLOGY, 2023, 34 (07) : 2608 - 2616
  • [6] Milk fat triacylglycerols and their relations with milk fatty acid composition, DGAT1 K232A polymorphism, and milk production traits
    Tzompa-Sosa, D. A.
    van Valenberg, H. J. F.
    van Aken, G. A.
    Bovenhuis, H.
    JOURNAL OF DAIRY SCIENCE, 2016, 99 (05) : 3624 - 3631
  • [7] Effect of DGAT1 variant (K232A) on milk traits and milk fat composition in outdoor pasture-grazed dairy cattle
    Li, Yunhai
    Zhou, Huitong
    Cheng, Long
    Edwards, Grant R.
    Hickford, Jonathan G. H.
    NEW ZEALAND JOURNAL OF AGRICULTURAL RESEARCH, 2021, 64 (01) : 101 - 113
  • [8] The DGAT1 K232A mutation is not solely responsible for the milk production quantitative trait locus on the bovine chromosome 14
    Bennewitz, J
    Reinsch, N
    Paul, S
    Looft, C
    Kaupe, B
    Weimann, C
    Erhardt, G
    Thaller, G
    Kühn, C
    Schwerin, M
    Thomsen, H
    Reinhardt, F
    Reents, R
    Kalm, E
    JOURNAL OF DAIRY SCIENCE, 2004, 87 (02) : 431 - 442
  • [9] The DGAT1 gene K232A mutation is associated with milk fat content, milk yield and milk somatic cell count in cattle (Short Communication)
    Manga, Ivan
    Riha, Honza
    ARCHIV FUR TIERZUCHT-ARCHIVES OF ANIMAL BREEDING, 2011, 54 (03): : 257 - 263
  • [10] Association of DGAT1 With Cattle, Buffalo, Goat, and Sheep Milk and Meat Production Traits
    Khan, Muhammad Zahoor
    Ma, Yulin
    Ma, Jiaying
    Xiao, Jianxin
    Liu, Yue
    Liu, Shuai
    Khan, Adnan
    Khan, Ibrar Muhammad
    Cao, Zhijun
    FRONTIERS IN VETERINARY SCIENCE, 2021, 8