Influence of surfactants on the physical stability of Solid Lipid Nanoparticle (SLN) formulations

被引：0
|
作者：
Üner, M [1 ]
Wissing, SA
Yener, G
Müller, RH
机构：
[1] Univ Istanbul, Fac Pharm, Dept Pharmaceut Technol, TR-34119 Istanbul, Turkey
[2] Free Univ Berlin, Dept Pharmaceut Biopharmaceut & Biotechnol, D-1000 Berlin, Germany
来源：
PHARMAZIE | 2004年 / 59卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The choice of surfactant or surfactant mixtures at suitable concentrations contributes to the stability of solid lipid nanoparticles (SLN). In this study, it was found that 1.5% TegoCare(R) 450 was the most effective stabilizer for the Witepsol(R) E85 SLN dispersion compared to Tween(R) 80, Tyloxapol(R) and Pluronic(R) F68 according to the data obtained from differential scanning calorimetry (DSC), zeta potential (ZP) measurements and particle size analysis.
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页码：331 / 332
页数：2
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