Breast Cancer Stem Cells and Sex Steroid Hormones

被引：5
|
作者：
Flores-Ramirez, Ivan [1 ,2 ]
Baranda-Avila, Noemi [2 ]
Langley, Elizabeth [2 ]
机构：
[1] Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Biomed, Cdmx, Mexico
[2] Inst Nacl Cancerol, Dept Invest Basica, Av San Fernando 22,Col Sect 16, Tlalpan 14080, Cdmx, Mexico
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2019年 / 14卷 / 05期
关键词：
Breast cancer; breast cancer stem cells; biomarkers; signaling pathways; estrogen receptor; progesterone receptor; ALDEHYDE DEHYDROGENASE; SELF-RENEWAL; PROGESTERONE-RECEPTOR; ALDH1; EXPRESSION; CD44; PROGENITOR; ESTROGEN; TUMORS; CXCR4; CD24;
D O I：
10.2174/1574888X13666180810121415
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes breast cancer stem cell origin, signaling pathways involved in self-renewal, such as Wnt, Notch and Hedgehog, biomarkers linked to sternness, and the role of sex steroid hormones in BCSC regulation.
引用
收藏
页码：398 / 404
页数：7
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