Cross-condensation of derivatives of cyanoacetic acid and carbonyl compounds -: 2.: One-pot synthesis of substituted 2-amino-7-methyl-5-oxo-4,5-dihydropyrano[4,3-b]pyrans in ethanol and ionic liquid [bmim][PF6]

被引：19
|
作者：
Shestopalov, AM [1 ]
Zlotin, SG [1 ]
Shestopalov, AA [1 ]
Mortikov, VY [1 ]
Rodinovskaya, LA [1 ]
机构：
[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2004年 / 53卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
malononitrile; carbonyl compounds; 2-amino-7-methyl-5-oxo-4,5-dihydropyrano[4,3-b]pyrans; isatin; 4-hydroxy-6-methylpyran-2(2H)-one; spiropiperidinoisoquinoline; ionic liquids;
D O I：
10.1023/B:RUCB.0000035640.47443.a4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The three-component reaction of 4-hydroxy-6-methylpyran-2(2H)-one with cyanoacetic acid derivatives and carbonyl compounds in EtOH or in the ionic liquid, viz., 1-butyl-3methylimidazolinium hexafluorophosphate ([bmim][PF6]), affords substituted 2-amino-7methyl-5-oxo-4,5-dihydropyrano[4,3-b]pyrans. The yield of substituted pyrano[4,3-b]pyrans in [bmim][PF6] is by 10-14% higher than that in EtOH.
引用
收藏
页码：573 / 579
页数：7
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