A new regioselective synthesis and bioactivity of 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives

被引：25
|
作者：
Wang, HQ
Liu, ZJ [1 ]
Yang, LM
Ding, MW
机构：
[1] Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China
[2] NanHua Univ, Coll Chem & Chem Engineer, Hengyang 421001, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2004年 / 41卷 / 03期
关键词：
D O I：
10.1002/jhet.5570410314
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one Derivatives 5 has been designed and regioselectively synthesized via a tandem aza-Wittig reaction. The structures of all compounds prepared have been confirmed by H-1 NMR, IR, EI-MS spectroscopy and elemental analyses. The results of preliminary bioassay indicate that most compounds 5 possess an inhibition effect against Botrytis cinereapers and Pyricularia oryzae at the concentration of 50 mg/L.
引用
收藏
页码：393 / 397
页数：5
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