Silica nanoparticles with Tb(III)-centered luminescence decorated by Ag0 as efficient cellular contrast agent with anticancer effect

被引：9
|
作者：
Fedorenko, Svetlana V. [1 ]
Grechkina, Svetlana L. [1 ]
Mukhametshina, Alsu R. [1 ]
Solovieva, Anastasiya O. [2 ,3 ]
Pozmogova, Tatiana N. [2 ]
Miroshnichenko, Svetlana M. [2 ,4 ]
Alekseev, Alexander Y. [3 ]
Shestopalov, Michael A. [2 ,3 ,5 ]
Kholin, Kirin V. [1 ]
Nizameev, Irek R. [1 ]
Mustafina, Asiya R. [1 ]
机构：
[1] Russian Acad Sci, Kazan Sci Ctr, AE Arbusov Inst Organ & Phys Chem, Arbusov St 8, Kazan 420088, Russia
[2] RAS, Res Inst Clin & Expt Lymphol, Branch ICG SB, 2 Timakova Srt, Novosibirsk 630060, Russia
[3] Res Inst Expt & Clin Med, 2 Timakova Str, Novosibirsk 630060, Russia
[4] Sci Inst Biochem, 2 Timakova St, Novosibirsk 630060, Russia
[5] RAS, Nikolaev Inst Inorgan Chem SB, 3 Acad Lavrentiev Ave, Novosibirsk 630090, Russia
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2018年 / 182卷
基金：
俄罗斯基础研究基金会;
关键词：
Silica nanoparticles; Lanthanide; Silver nanoparticles; Cytotoxicity; Cellular uptake; Anticancer activity; UP-CONVERSION NANOPARTICLES; SILVER NANOPARTICLES; CENTERED LUMINESCENCE; CANCER-THERAPY; HUMAN-CELLS; IN-VITRO; THIACALIXARENE; IONS;
D O I：
10.1016/j.jinorgbio.2018.02.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present work introduces composite luminescent nanoparticles (Ag-0-Tb3+-SNs), where ultra-small nanosilver (4 +/- 2 nm) is deposited onto amino -modified silica nanoparticles (35 +/- 6 run) doped by green luminescent Tb (III) complexes. Ag-0-Tb3+-SNs are able to image cancer (Hep-2) cells in confocal microscopy measurements due to efficient cell internalization, which is confirmed by TEM images of the Hep-2 cells exposed by Ag-0-Tb3+-SNs. Comparative analysis of the cytotoxicity of normal fibroblasts (DK-4) and cancer cells (Hep-2) incubated with various concentrations of Ag-0-Tb3+-SNs revealed the concentration range where the toxic effect on the cancer cells is significant, while it is insignificant towards the nonmalignant fibroblasts cells. The obtained results reveal Ag-0-Tb3+-SNs as good cellular contrast agent able to induce the cancer cells death, which makes them promising theranostic in cancer diagnostics and therapy.
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收藏
页码：170 / 176
页数：7
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