Inhibitors of the TGF-β superfamily and their clinical applications

被引：29
|
作者：
Tsuchida, K. [1 ]
Sunada, Y.
Noji, S.
Murakami, T.
Uezumi, A.
Nakatani, M.
机构：
[1] Fujita Hlth Univ, Div Therapies Intractable Dis, Inst Comprehens Med Sci, Toyoake, Aichi 4701192, Japan
[2] Kawasaki Med Sch, Div Neurol, Dept Internal Med, Kurashiki, Okayama 7010192, Japan
[3] Univ Tokushima, Fac Engn, Dept Biol Sci & Technol, Tokushima 7708506, Japan
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 11期
关键词：
TGF-beta; activin; BMP; cancer; fibrosis; follistatin; myostatin; muscular dystrophy;
D O I：
10.2174/138955706778742759
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The transforming growth factor-beta (TGF-beta) superfamily includes TGF-beta s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-beta family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-beta superfamily regulate fine-tuning of activity of TGF-beta family in vivo. In addition to natural inhibitors for the TGF-beta family, soluble forms of receptors for the TGF-beta family, blocking monoclonal antibodies and small chemical TGF-beta inhibitors have been developed. In this review, we summarize recent advances in our understanding of inhibitors for the TGF-beta superfamily and their medical applications.
引用
收藏
页码：1255 / 1261
页数：7
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