ERp57 modulates mitochondrial calcium uptake through the MCU

被引：16
|
作者：
He, Jingquan [1 ]
Shi, Weikang [1 ]
Guo, Yu [1 ]
Chai, Zhen [1 ]
机构：
[1] Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
来源：
FEBS LETTERS | 2014年 / 588卷 / 12期
基金：
中国国家自然科学基金;
关键词：
ERp57; MCU; Mitochondrial calcium uptake; PROTEIN; UNIPORTER; MICU1; ACTIVATION; CHAPERONE; INJURY;
D O I：
10.1016/j.febslet.2014.04.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
ERp57 participates in the regulation of calcium homeostasis. Although ERp57 modulates calcium flux across the plasma membrane and the endoplasmic reticulum membrane, its functions on mitochondria are largely unknown. Here, we found that ERp57 can regulate the expression of the mitochondrial calcium uniporter (MCU) and modulate mitochondrial calcium uptake. In ERp57-silenced HeLa cells, MCU was downregulated, and the mitochondrial calcium uptake was inhibited, consistent with the effect of MCU knockdown. When MCU was re-expressed in the ERp57 knockdown cells, mitochondrial calcium uptake was restored. Thus, ERp57 is a potent regulator of mitochondrial calcium homeostasis. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2087 / 2094
页数：8
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